A kind of linseed oil liposome and its preparation and application

A technology of oil liposome and linseed oil, which is applied in cosmetic preparations, cosmetic preparations, preparations for skin care, etc., can solve the problems of oxidative deterioration, affect functional effects, etc., and achieve strong and sustainable skin penetration ability. Long-lasting, stable effect

Active Publication Date: 2019-07-16
前研化妆品科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the unsaturated fatty acids in linseed oil are extremely unstable, they are easily oxidized and deteriorated by environmental conditions such as light and heat, which seriously affects their functional effects.

Method used

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  • A kind of linseed oil liposome and its preparation and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Raw material ratio: 100g of phospholipids, 30g of cholesterol, 15g of polyethylene glycol laurate, 10g of linseed oil, 0.10g of vitamin E, 0.10g of vitamin C, and 3.0g of collagen.

[0039] 2. Preparation of linseed oil liposomes:

[0040] (1) Add 1000mL of absolute ethanol to phospholipids, cholesterol, and polyethylene glycol laurate according to the formula, mix at 40-50°C and fully stir until dissolved to obtain solution a;

[0041] (2) Fully stir and mix the linseed oil, vitamin E, vitamin C and collagen according to the formula quantity to obtain solution b;

[0042] (3) adding the above-mentioned solution b to the solution a obtained in step (1), stirring evenly to obtain the solution c;

[0043] (4) Drop solution c into a phosphate buffer solution with a temperature of 58°C, a pH of 7.0, and a volume of 2500 mL at a rate of 1 drop per second, and stir to form a suspension;

[0044] (5) Ethanol is removed by vacuum rotary evaporation of the suspension at 40-...

Embodiment 2

[0048] 1. Raw material ratio: 100g of phospholipids, 25g of cholesterol, 20g of polyethylene glycol laurate, 12g of linseed oil, 0.15g of vitamin E, 0.10g of vitamin C, and 2.0g of resveratrol.

[0049] 2. Preparation of linseed oil liposomes:

[0050] (1) Add 1000mL of absolute ethanol to phospholipids, cholesterol, and polyethylene glycol laurate according to the formula, mix at 40-50°C and fully stir until dissolved to obtain solution a;

[0051] (2) Fully stir and mix the linseed oil, vitamin E, vitamin C and resveratrol according to the formula quantity to obtain solution b;

[0052] (3) adding the above-mentioned solution b to the solution a obtained in step (1), stirring evenly to obtain the solution c;

[0053] (4) Drop solution c into a phosphate buffer solution with a temperature of 60°C, a pH of 6.8, and a volume of 3000 mL at a rate of 1 drop per second, and stir to form a suspension;

[0054] (5) Ethanol is removed by vacuum rotary evaporation of the suspension ...

Embodiment 3

[0058] 1. Raw material ratio: 100g of phospholipids, 35g of cholesterol, 23g of polyethylene glycol 400, 15g of linseed oil, 0.20g of vitamin E, 0.20g of vitamin C, 3.0g of liquiritigenin.

[0059] 2. Preparation of linseed oil liposomes:

[0060] (1) Add 1000mL of absolute ethanol to phospholipids, cholesterol, and polyethylene glycol 400 according to the formula, mix at 40-50°C and fully stir until dissolved to obtain solution a;

[0061] (2) Fully stir and mix the linseed oil, vitamin E, vitamin C, and glycyrrhizin according to the formula to obtain solution b;

[0062] (3) adding the above-mentioned solution b to the solution a obtained in step (1), stirring evenly to obtain the solution c;

[0063] (4) Drop solution c into a phosphate buffer solution with a temperature of 55°C, a pH of 6.6, and a volume of 4000 mL at a rate of 1 drop per second, and stir to form a suspension;

[0064] (5) Ethanol is removed by vacuum rotary evaporation of the suspension at 40-60° C. to ...

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Abstract

The invention discloses a flaxseed oil liposome and a preparation method and applications thereof. The flaxseed oil liposome is prepared from the following raw materials in parts by weight: 100 parts of phospholipid, 10 to 50 parts of cholesterol, 10 to 50 parts of surfactant, 5 to 20 parts of flaxseed oil, 0.05 to 0.5 part of antioxidant, and 0.2 to 5 parts of cosmetic active component. The content of alpha-linolenic acid of the flaxseed oil liposome is high, the property of the alpha-linolenic acid is stable, at the same time, the skin penetrating performance of the alpha-linolenic acid and active components becomes stronger under the effect of the liposome, and thus the skincare effect becomes better, and can last for a longer time. The technology is matured and simple, and is suitable for industrial production. The content of alpha-linolenic acid of the flaxseed oil liposome is not less than 0.10%, and the particle size of the alpha-linolenic acid is 10 to 100 nm.

Description

[0001] (1) Technical field [0002] The invention belongs to the technical field of cosmetics, and in particular relates to a linseed oil liposome and a preparation method thereof. [0003] (2) Background technology [0004] With the rapid development of the economy, people's living standards have improved while the quality of the living environment has declined, and the pace of life has accelerated and the work pressure has intensified. , dry and dehydrated skin, and aggravated aging. Therefore, people pay more attention to skin care and beauty, and the requirements for cosmetics are no longer limited to covering, but are required to have functions such as protection, skin repair and beauty. [0005] Flaxseed oil is rich in unsaturated fatty acids, of which α-linolenic acid content can reach more than 50%. α-linolenic acid has excellent affinity and penetration to the skin, and can easily penetrate the surface layer to the deep layer of the skin to supplement the lipid nutri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/14A61K8/34A61K8/49A61K8/65A61K8/73A61K8/92A61Q19/00
CPCA61K8/14A61K8/347A61K8/498A61K8/65A61K8/735A61K8/922A61K2800/592A61Q19/00
Inventor 唐振兴梁洁玉施明珠卞继州
Owner 前研化妆品科技(上海)有限公司
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