Probiotic fermented Senzhujianzhong oral liquid and preparation method thereof

A probiotic and fermentation type technology, applied in the field of medicine, can solve problems such as waste of medicinal materials, and achieve the effects of increasing gastrin content, enriching flavor substances, and improving therapeutic effects

Inactive Publication Date: 2017-02-15
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to overcome the defect that the current Shenshu Jianzhong oral liquid adopts alcohol precipitation process to remove polysaccharides, polypeptides and other macromolecular components in the prescription, resulting in waste of medicinal materials, and to provide a probiotic fermented Shenshu Jianzhong oral liquid Liquid and its preparation method

Method used

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  • Probiotic fermented Senzhujianzhong oral liquid and preparation method thereof
  • Probiotic fermented Senzhujianzhong oral liquid and preparation method thereof
  • Probiotic fermented Senzhujianzhong oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of Probiotic Fermented Shenzhu Jianzhong Oral Liquid A

[0030] Weigh each Chinese medicine ingredient according to the following weight: ginseng 50g, burnt hawthorn 50g, Schisandra chinensis 20g, fried malt 10g, Jiaobaizhu 10g.

[0031] Take ginseng, fried malt, and Jiaobaizhu three herbs, crush them, pass through 20 meshes, add 10 times the amount of water to soak for 1.0 hours, heat at 110°C for 20 minutes, and when the temperature is lowered to 90°C, adjust the pH to 6, add 0.2g of high-temperature amylase, Enzymolysis until the iodine test solution no longer turns blue.

[0032] Adjust the pH to 7.0 and sterilize at 115°C for 50 minutes. When the temperature drops to about 39°C, inoculate pre-cultured Bifidobacterium bifidum with a volume percentage of about 0.5% (isolated from normal human body, identified by the Institute of Microbiology, Chinese Academy of Sciences) ) and Bifidobacterium adolescentis (CGMCC 1.2190), cultured at 37°C for a...

Embodiment 2

[0035] Example 2: Preparation of probiotic fermented Shenshu Jianzhong Oral Liquid B

[0036] Weigh each Chinese medicine ingredient according to the following weight: ginseng 50g, burnt hawthorn 50g, Schisandra chinensis 20g, fried malt 10g, Jiaobaizhu 10g.

[0037] Take ginseng, fried malt, and Jiaobaizhu three herbs, crush them, pass through 60 mesh, add 10 times the amount of water to soak for 0.5 hours, heat at 100°C for 40 minutes, when the temperature is lowered to 80°C, adjust the pH to 6.2, add 0.3g of high-temperature amylase, Enzymolysis until the iodine test solution no longer turns blue.

[0038] Adjust the pH to 7.0 and sterilize at 121°C for 40 minutes. When the temperature drops to about 39°C, at the same time inoculate the pre-cultured B. 0.5% of Lactobacillus acidophilus (CGMCC 1.1854) and Lactobacillus plantarum (CGMCC 1.19) bacteria solution, fermented at 37°C for 24 hours to check the pH value, when the pH value dropped below 4.0, the fermentation was ter...

experiment example 1

[0044] Experimental Example 1: Function experiment of probiotic fermented Shenshu Jianzhong Oral Liquid and original craft Shenshu Jianzhong Oral Liquid for nourishing Qi and invigorating spleen

[0045] The purpose of this experiment is to use the determination of the content of nitric oxide, nitric oxide synthase and gastrin in the serum and gastrointestinal tissue of rats with spleen deficiency syndrome, and to describe the fermented ginseng Jianzhong oral preparation prepared by the method of the present invention by way of example. Liquid, compared with the functional effect of Shenshu Jianzhong Oral Liquid prepared by the original process.

[0046] Take the probiotic fermented Shenshu Jianzhong Oral Liquid prepared in Examples 1 and 2 and the Shenshu Jianzhong Oral Liquid prepared by the original process (produced by Sanzhu Fuer Pharmaceutical Co., Ltd., batch number 151001), and concentrate to the same concentration respectively (according to The amount of medicinal mat...

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Abstract

The invention discloses probiotic fermented Senzhujianzhong oral liquid and a preparation method thereof. The probiotic fermented compound traditional Chinese medicine (the oral liquid) is prepared from ginseng, parched hawthorn fruits, fruits of Chinese magnoliavine, roasted malt and deep-fried atractylodes macrocephala koidz. Experiments prove that the probiotic fermented Senzhujianzhong oral liquid prepared by the invention can significantly increase and improve such indicators as nitric oxide content, nitric oxide synthase content, gastrin and the like in serum and gastrointestinal tissue of rat with symptom of spleen qi deficiency; and the oral liquid is better than Senzhujianzhong oral liquid which is prepared by virtue of an original process in function on treating such symptoms as food stagnation, distention and oppression in stomach duct, indigestion and loss of appetite, insomnia and dreaminess, dizziness and heart palpitations, lassitude of spirit and weakness, and the like.

Description

technical field [0001] The invention relates to a probiotic fermented Shenzhu Jianzhong oral liquid for treating symptoms such as stagnation in diet, epigastric distension, lack of appetite, insomnia and dreaminess, dizziness, palpitations, fatigue and fatigue, and a preparation method thereof, which belongs to medical technology field. Background technique [0002] Shenshu Jianzhong Oral Liquid prepared according to the preparation method given in the pharmaceutical standard WS-5523 ​​(B-0523)-2002 is a kind of oral liquid that has the functions of nourishing qi, invigorating the spleen, and calming the nerves in the middle, and is suitable for treating dietary stagnation, Oral preparations for epigastric distension, poor appetite, insomnia and dreaminess, dizziness, palpitations, and fatigue. The following is the formula, process and brief description given in WS-5523(B-0523)-2002 drug standard: [0003] Prescription: ginseng 50g, hawthorn (burnt) 50g, schisandra 20g, ma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8998A61K47/26A61P1/14A61P25/20A61P9/06A61P39/00A61P1/08
CPCA61K36/258A61K9/0053A61K36/284A61K36/57A61K36/734A61K36/79A61K36/8998A61K47/26A61K2236/19A61K2236/331A61K2236/39A61K2300/00
Inventor 吴炳新褚新红孙筱林甄宗武祝晓风
Owner SANZHU FUER PHARMA
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