Stephanine and its pharmaceutically acceptable salt and application of solvate for preparing antiarrhythmic medicine

Abstract

The invention relates to stephanine and its pharmaceutically acceptable salt and an application of a solvate for preparing an antiarrhythmic medicine, which belongs to the technical field of medicine. A structural formula of stephanine is shown as a formula (I); the researches on chloroform-induced mice arrhythmia show that stephanine can resist chloroform-induced ventricular fibrillation, preliminary determination is confirmed that the stephanine has antiarrhythmic effect; then barium chloride-induced rat ventricular rhythm test, aconitine intravenous injection-induced rat cardiac rhythm test and rat myocardial ischemia and ischemia reperfusion arrhythmia test are carried out, so that stephanine has good antiarrhythmic effect, and provides a good base for preparing various antiarrhythmic medicines next time.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of stephine and pharmaceutically acceptable salts and solvates thereof as preparation of antiarrhythmic drugs. Background technique [0002] Cardiac arrhythmia refers to abnormalities in the frequency, rhythm, origin, conduction velocity, or sequence of cardiac impulses. Arrhythmia is an important group of diseases in cardiovascular diseases. It can occur alone or accompany other cardiovascular diseases. Its prognosis is related to the etiology, inducement, evolution trend of arrhythmia, and whether it leads to severe hemodynamic disturbance. It can occur suddenly and cause sudden death, or it can continue to involve the heart and cause it to fail. Although there are radiofrequency ablation and other treatment methods, antiarrhythmic drugs are still the main treatment method or an essential part of it. For a long time, people have been unremittingly...

AI Technical Summary

Problems solved by technology

[0004] Most commonly used antiarrhythmic drugs currently on the market are accompanied by adverse reactions that cannot be ignored. For example, lidocaine often manifests as dizziness, paresthesia, confusion and other nervous system adverse reactions, while amiodarone has hypothyroidism or hyperthyroidism, and lung damage. Adverse reactions such as cardiovascular, neurological, endocrine and other adverse reactions may occur if the dosage of verapamil is not adjusted properly

How to overcome the problem of adverse reactions of antiarrhythmic drugs in the prior art is an urgent problem to be solved at present

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