Menispermum dahuricum dc.extract,the extractive process and the application thereof

Abstract

The present invention relates to a menispermum dauricum phenolic bae extracted from menispermum dauricum root and stem coarse powder and its extraction method. It includes the following steps: firstly, extracting biological total base from coarse powder of menispermum dauricum root and stem, alkalizing to obtain crude total base deposit, using ethyl alcohol to extract phenolic base to obtain brown paste-like material, dissolving with alkali, filtering, adding acid in phenolic base aqueous solution to make neutralization, filtering and collecting deposit, and drying so as to obtain the phenolic base product. Said invented menispermum dauricum phenolic base product possesses the function of resisting arrhythmia, and has no drug pedendence. Its preparation process is simple, has no pollution, and its yield is high and cost is low.

Description

technical field [0001] The invention relates to an alkaloid extracted from the rhizome of Pueraria puerariae, its extraction process and its application in pharmacy. Background technique [0002] The total alkaloids of bat kudzu was once used as a heat-clearing and detoxifying drug under the name of Beidougen Tablets. It was used to treat sore throat, tonsillitis, and chronic bronchitis. In 1980, we discovered that dauricine has antihypertensive effects, and later found that it has antiarrhythmic, anti-myocardial ischemia, and anti-platelet aggregation effects. In 1985, we had clinical trials and proved that the drug has anti-arrhythmic effects. The patients had a good curative effect, and the effective rate reached 91.5%. Because the method for separating and extracting dauricine units is cumbersome and the yield is low [CN 1047861A], the drug development work has not been realized so far. [0003] Cardiovascular disease is a frequently-occurring clinical disease, and arr...

AI Technical Summary

Problems solved by technology

Because the method for the separation and extraction of dauricine unit body is cumbersome and the yield is low [CN 1047861A] so its drug development work has not been realized so far

[0003] Cardiovascular disease is a frequently-occurring clinical disease, and arrhythmia is a dangerous sign of cardiovascular disease. At present, there are still many shortcomings in existing antiarrhythmic drugs, and many drugs may have adverse drug dependence, such as quinidine and sotalol. Therefore, it is easy to cause early afterdepolarization, triggered activity, and even torsades de pointes

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