The invention relates to a brominated crebanine compound and preparation method and an application thereof, which belongs to the technical field of
medicine. The invention firstly discloses the synthesis of 3-brominated crebanine and 10, 11-brominated crebanine, through research on effect of
chloroform for inducing mice arrhythmia, the research shows that the 3-brominated crebanine and 10, 11-brominated crebanine can antagonize the
chloroform-induced
ventricular fibrillation, so that the 3-brominated crebanine and 10, 11-brominated crebanine have anti-arrhythmia effect through preliminary determination; the
barium chloride-induced rat ventricular
rhythm tests confirm that the 3-brominated crebanine and 10, 11-brominated crebanine have good anti-arrhythmia effect,
acute toxicity of two brominated crebanine compounds is lower than that of crebanine, LD50 is 65.15+ / -1.132 mg / kg of 3-brominated crebanine and 59.62+ / -2.610 mg / kg of 10,11-brominated crebanine respectively, and a good base can be established for further deep researches.