91 results about "Cardiac pace" patented technology

A system for identifying locations for pacing the heart, the system comprising a pacing electrode, a remote navigation system for positioning the pacing electrode at each of a plurality of locations; a system for determining Pressure-Volume loop data resulting from pacing at each location; an ECG system, a phrenic nerve stimulation detection system, and a means of identifying at least one preferred location based upon at least the Pressure-Volume loop, ECG, and phrenic nerve stimulation data at each location. A method of identifying locations for pacing the heart, the method comprising: navigating a pacing electrode to each of a plurality of locations in the heart; pacing the heart at each of the plurality of locations; and assessing the effectiveness of the pacing at each location by measuring cardiac blood flow and cardiac wall strain.

A leadless implantable cardioverter defibrillator (5) for treatment of sudden cardiac death includes a controller and at least one remote module. The defibrillator does not require transvenous/vascular access for intracardiac lead placement. The controller is leadless and uses subcutaneous tissue in proximity of the chest and abdomen for both sensing and defibrillation. The controller and one or more remote sensors sense a need for defibrillation and wireless communicate with the controller. The controller and one of the sensors discharge a synchronized defibrillation pulse to the surrounding subcutaneous tissue in proximity to the heart.

Some method examples may include pacing a heart with cardiac paces, sensing a physiological signal for use in detecting pace-induced phrenic nerve stimulation, performing a baseline level determination process to identify a baseline level for the sensed physiological signal, and detecting pace-induced phrenic nerve stimulation using the sensed physiological signal and the calculated baseline level. Detecting pace-induced phrenic nerve stimulation may include sampling the sensed physiological signal during each of a plurality of cardiac cycles to provide sampled signals and calculating the baseline level for the physiological signal using the sampled signals. Sampling the sensed physiological signal may include sampling the signal during a time window defined using a pace time with each of the cardiac cycles to avoid cardiac components and phrenic nerve stimulation components in the sampled signal.

A cardiac rhythm management device includes a dual chamber pacemaker, especially designed for treating congestive heart failure. The device incorporates a program microcontroller which is operative to adjust the pacing site, AV delay and interventricular delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the site, AV delay and interventricular delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Paced transient beats following periods of baseline beats are synchronized to the patient's respiratory cycle to minimize effects of respiratory noise on atrial cycle length measurements.

Methods and devices for establishing and using baseline for cardiac pacing response detection are described. A baseline amplitude of the cardiac signal may be established using data acquired in an evaluation interval prior to the delivery of the pacing pulse. An amplitude of the cardiac signal following delivery of the pacing pulse may be referenced using the baseline amplitude. An evoked response from the pacing pulse is detected using the referenced cardiac signal amplitude.

Methods and systems involve determining the cardiac response to pacing pulses. The variability cardiac signal features detected during initialization is used to establish a variability threshold. A cardiac signal associated with a pacing pulse is sensed and one or more features of the cardiac signal are detected. The variability of the one or more features is compared to the variability threshold. The cardiac response to the pacing pulse is determined based on the feature variability.

This invention provides pacemaker systems comprising (1) an electronic pacemaker, and (2) a biological pacemaker, wherein the biological pacemaker comprises a cell that functionally expresses a chimeric hyperpolarization-activated, cyclic nucleotide-gated (HCN) ion channel at a level effective to induce pacemaker current in the cell. The invention also provides related biological pacemakers, atrioventricular bridges, methods of making same, and methods of treating a subject afflicted with a cardiac rhythm disorder.

The waveform morphology of a propagated pacing response signal may be adjusted to achieve a waveform morphology that enhances cardiac pacing response determination. One or more pacing intervals may be adjusted to achieve at least one cardiac pacing response waveform morphology that enhances determination of the cardiac pacing response. The heart is paced using the one or more adjusted pacing intervals and the cardiac response to the pacing is determined. The one or more adjusted pacing intervals may include an atrioventricular pacing delay, an interatrial pacing delay, an interventricular pacing delay, or other inter-chamber or inter-site pacing delays. Adjusting the one or more pacing intervals may be used to increase a difference between a first waveform morphology associated with multi-chamber capture and a second waveform morphology associated with single chamber capture.

Cell transplantation for constructing biological heart pacemaker is used embryo source dry/ancestral cell and adult mesogalia dry cell as cell sources. The process is carried out by oriented differentiation inducing for heart pacemaker cell by embryo source multifunctional dry cell, bone marrow adhering to obtain primary culture cell, clone culturing to obtain purifying system by diluting, applying paracrine factor endothelin-1 or nervous adjusting protein-1, extracellular matrix laminated adherent protein and fiber connecting protein etc. substrate glue, trans-dyeing pacemaker gene HCN4, and in-vitro inducing embryo source multifunctional dry cell. It is various and non-immunogenicity. It can be used to treat sick sinus syndrome.

The invention provides a heart pacing device, and a fixing method and a conveying system thereof; the heart pacing device comprises an annular support and a wireless pacing unit at least partially arranged on the annular support; the annular support has a first size with the rebound limited by the first environment, and expands to a second size under the second environment. The heart pacing devicecan be fixed in human body tissues of different wall thicknesses and sizes, and can be easily fixed in a boundary place between the postcava and the right atrium, realizing dual-cavity pacing of thewireless pacing unit, and ensuring the atrium-chamber synchronization physiological pacing. The heart pacing device uses the self-expansion features of the annular support to tightly attach the annular support with protogenesis blood vessel walls, thus fixing the heart pacing device in the heart chamber with a good fixing effect, and preventing heart chamber perforating risks.

A method and apparatus for preventing atrial fibrillation arising from a premature atrial contraction. Upon detection of a premature atrial contraction, a pace is delivered to a ventricle at a specified AV interval selected as either a late-pace or early-pace value. The resulting ventricular depolarization then occurs during a time when the atria are not vulnerable to the triggering of fibrillation.

The present disclosure relates generally to pacing of cardiac tissue, and more particularly to adjusting delivery of His bundle or bundle branch pacing in a cardiac pacing system to achieve synchronized ventricular activation. A left bundle branch (LBB) cathode electrode may be implanted a left side of the septum of the patient's heart proximate to the LBB, and a right bundle branch (RBB) cathode electrode may be implanted on a right side of the septum of the patient's heart proximate to the RBB. One or both cathode electrodes may be used to deliver synchronized left and right bundle-branch pacing based on one or both of an atrial event and a ventricular event. A device for bundle branch pacing may be implanted based on determining whether an LBB block pattern or an RBB block pattern is present in monitored electrical activity.

The invention discloses a flexible ventricle assist device which comprises an elastic shell attached to the outer wall of the heart and at least two sets of pneumatic muscles embedded in the elastic shell and corresponding to the left ventricle and the right ventricle of the heart respectively. An air passage for communicating the air bags in all the pneumatic muscles is arranged in the elastic shell, and is led out through an air inlet and an air outlet in the elastic shell to be connected with an external air source; and a strain limiting layer is arranged on the outer side air bag wall, away from the heart, of the pneumatic muscle. The heart pump blood function of a heart failure patient can be assisted; the whole device is simple in structure, and the elastic shell can be designed to be lighter and thinner; the load of the implantation device on the body of the patient is reduced; the whole elastic structure can better adapt to different biological characteristics adapting to hearts of different patients, is wider in adaptability, can act on the heart to conduct adaptive deformation on torsion of the heart in the heart process, reduces damage to cardiac myocardium of the heart,and enables the heart of the heart failure patient to reach the normal blood pumping level through heart pacing signal feedback control.

A network of electrodes configured to sense and/or pace the heart, wherein the network of electrodes are in contact with an epicardial surface of the heart, within a wrapping sleeve that assist the heart as a whole, wherein the network of electrodes sense the heart by quantifying intrinsic electrical activities of the heart, and wherein the network of electrodes pace the heart by inducing an electrical impulse to the heart to control its contractile activities. The network may be interfaced with a controller system, wherein the controller uses spatial and temporal electrical activities of the heart muscles to generate electrical impulse to synchronize the wrapping sleeve around the heart with the heart. Also disclosed is a system configured to construct space-time mapping of cardiac electrical activities and/or propagation, and sensing effects of a first assist event of a prior beat and controlling a second assist event.

Methods, systems and computer program products for combining atrial defibrillation treatment techniques include techniques for reducing the discomfort associated with defibrillation and/or reducing the defibrillation threshold. Techniques include timing the defibrillation shock to reduce discomfort based on a sensed signal, giving the shock relatively early during atrial fibrillation, therapeutic drugs, administering more than one shock in succession, pacing the heart before, after, or during the defibrillation shock or shocks, and placing the shock electrodes in locations that may reduce discomfort.

The present disclosure relates to devices and methods for cardiac pacing therapy. Disclosed herein are methods for His bundle cardiac pacing; cardiac leads and leadless cardiac pacemakers that enables pacing and sensing of the His bundle as well as the right atrium and right ventricle; and delivery sheaths for placing the cardiac lead or leadless cardiac pacemaker in the heart. The devices and methods disclosed increase the success at which His bundle pacing can be implemented.

A device and method for providing cardiac pacing of triangle of Koch and bundle of His zones by multiple electrodes inserted using in a single conduit are provided. The method includes providing a single conduit with multiple electrodes, positioning electrodes in the target zone of a heart, selecting acceptable electrodes as active based on a predetermined criteria and providing cardiac stimulation for multiple chambers of the heart from a single location.

The invention discloses an optional technology of an invasive temporary cardiac on-demand pace-making sensing source. According to the optional technology of the invasive temporary cardiac on-demand pace-making sensing source, a self-developed temporary cardiac on-demand pacemaker is connected and combined with a monitor in a matched manner; a combined pace-making and monitoring integrated instrument provides a more reliable pacing-sensing technology; the pacemaker collects intracardiac electrocardiogram signals through a pace-making electrode; the intracardiac electrocardiogram signals are transmitted to the monitor through using a communication module; intubation medical staff observe an intracardiac electrocardiogram through the monitor, and accurately judges a location where the electrode is located based on a synchronous surface electrocardiogram; after the pace-making electrode is led to a proper position, the pacemaker carries out on-demand pace-making on ventricles; as for the problem of difficulty in fixing a pace-making position in the clinical temporary cardiac pace-making VVI technology, the integrated pace-making and monitoring integrated technology can greatly improve the understanding of the medical staff on pace-making states greatly; and as for the problem of difficult processing caused by a situation that a clinical temporary cardiac on-demand pace-making sensing source is unreliable, surface electrocardiogram R waves from the monitor are provided and are adopted as a stable ventricular pace-making source.

The application discloses a heart rate variability analysis method and device. The method comprises the steps: collecting electrocardiogram signals; analyzing the collected electrocardiogram signalsto obtain RR intervals of the electrocardiogram signals, drawing a three-dimensional electrocardiogram scatter diagram according to the RR intervals of the electrocardiogram signals, the RR intervalsbeing the R wave duration of two adjacent QRS waves on an electrocardiogram; dividing each clustering block mass in the three-dimensional electrocardiogram scatter diagram into clustering block masseswith different attributes, each clustering block mass being a point set formed by cardiac pacing points; and respectively determining heart rate variability indexes of the clustered masses with different attributes. According to the method and the device, when the HRV is analyzed by adopting the traditional electrocardiogram scatter diagram, two adjacent RR intervals are used for drawing on a plane, the situation of heart beat point set overlapping is likely to happen under the condition of arrhythmia diversification, and a researcher is difficult to conduct quantitative analysis of thoroughand effective heart rate variability on an electrocardiogram scatter diagram.

A leadless cardiac pacemaker is adapted for implantation into triangle of Koch or His bundle with a plurality of individual electrodes spread in the vicinity of implantation site. Individual electrodes are first evaluated for their suitability for sensing and pacing of atrial and ventricular chambers of the heart. Individual electrodes are then selected for delivery of cardiac pacing to multiple heart chambers from a single intra-cardiac location. Remaining non-selected individual electrodes may be abandoned. Also described is an adapter with multiple electrodes configured to dock with a conventional leadless or standard pacemaker to operate in the same way.