A method for continuous production of 5-chloro-2-pentanone

A pentanone and chlorination reaction technology, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve problems such as difficult post-processing, poor economy of chlorine atoms, unstable product quality, etc.

Active Publication Date: 2020-10-27
淄博齐塑环保科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in these existing technologies, hydrochloric acid is used as the source of chlorination, wherein hydrochloric acid is rich in 70% water, and a large amount of high-chlorinated waste water will be produced after chlorination, and the aftertreatment is difficult, and the economy of chlorine atoms is relatively poor, and the product quality is not good. Phenomena such as stability
In the more traditional process, thionyl chloride, phosphorus trichloride, phosphorus pentachloride, etc. are used as chlorination reagents, all of which have many side reactions and difficult treatment of waste water and waste gas; these problems need to be solved urgently

Method used

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  • A method for continuous production of 5-chloro-2-pentanone

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Experimental program
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Effect test

Embodiment 1

[0021] The used reactor 1 of the chlorination reaction operation is a tower reactor or a tank reactor with a steaming column; hydrogen chloride gas enters from the bottom of the reactor 1 at a speed of 38kg / h, and 2000kg3-acetylpropanol enters at the bottom of the reactor 1 at a rate of 200kg / h. The speed enters from the top of the reactor 1, the reaction temperature in the reactor 1 is 50°C, the reaction pressure is 0.4MPa, and the material mixing reaction time is 172min; after the materials are fully mixed and reacted, the material at the bottom of the reactor 1 is transported into the azeotropic distillation tower 3 ;

[0022] In the azeotropic distillation process, the mixture containing material and water from the reactor 1 is distilled through the azeotropic distillation tower 3; The distillate enters the water separation tank 7 after being condensed by the condenser 5 to carry out the oil-water phase process, and the aqueous solution rich in hydrogen chloride in the upp...

Embodiment 2

[0025] The used reactor 1 of the chlorination reaction operation is a tower reactor or a tank reactor with a steaming column; hydrogen chloride gas enters from the bottom of the reactor 1 at a speed of 38kg / h, and 2000kg3-acetylpropanol enters at the bottom of the reactor 1 at a rate of 200kg / h. The speed enters from the top of the reactor 1, the reaction temperature in the reactor 1 is 52°C, the reaction pressure is 0.35MPa, and the material mixing reaction time is 176min; after the materials are fully mixed and reacted, the material at the bottom of the reactor 1 is transported into the azeotropic distillation tower 3 ;

[0026] In the azeotropic distillation process, the mixture containing material and water from the reactor 1 is distilled through the azeotropic distillation tower 3; The distillate enters the water separation tank 7 after being condensed by the condenser 5 to carry out the oil-water phase process, and the aqueous solution rich in hydrogen chloride in the up...

Embodiment 3

[0029]The used reactor 1 of the chlorination reaction operation is a tower reactor or a tank reactor with a steaming column; hydrogen chloride gas enters from the bottom of the reactor 1 at a speed of 38kg / h, and 2000kg3-acetylpropanol enters at the bottom of the reactor 1 at a rate of 200kg / h. The speed enters from the top of the reactor 1, the reaction temperature in the reactor 1 is 49°C, the reaction pressure is 0.45MPa, and the material mixing reaction time is 168min; after the materials are fully mixed and reacted, the material at the bottom of the reactor 1 is transported into the azeotropic distillation tower 3 ;

[0030] In the azeotropic distillation process, the mixture containing material and water from the reactor 1 is distilled through the azeotropic distillation tower 3; The distillate enters the water separation tank 7 after being condensed by the condenser 5 to carry out the oil-water phase process, and the aqueous solution rich in hydrogen chloride in the upp...

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Abstract

The invention relates to a method for continuously producing 5-chlorine-2-pentanone, which belongs to the technical field of an organic synthesis technology. The method is characterized by comprising a chlorination reaction, azeotropic distillation, and oil-water phase-splitting and dehydration; in the chlorination reaction, hydrogen chloride gas is introduced from bottom of a reactor (1), 3-acetylpropanol is introduced from top of the reactor (1), therein the reaction temperature in the reactor (1) is 48-55 DEG C, the reaction pressure is 0.3 MPa-0.5 MPa, the material mixing reaction time is 165-180 min; after the materials are fully mixed and reacted, the materials at the bottom of the reactor are conveyed to an azeotropic distillation tower (3). The hydrogen chloride gas is taken as a chlorination raw material, the hydrogen chloride gas is introduced from bottom of the reactor, 3-acetylpropanol is introduced from top of the reactor, two materials are fully mixed during a counter current process, and then are introduced into the bottom of the reactor for the chlorination reaction. The required temperature of the chlorination reaction is low, energy consumption is small, high chlorine waste water cannot be generated, and the product quality is stable.

Description

technical field [0001] A method for continuously producing 5-chloro-2-pentanone belongs to the technical field of organic synthesis. Background technique [0002] 5-Chloro-2-pentanone is an organic synthesis intermediate, widely used as an important raw material for the production of cyclopropylmethyl ketone, cyclopropylacetylene and other substances, and widely used for the synthesis of intermediates in the production of pharmaceuticals and pesticides. In the prior art, acetylbutyrolactone is used as raw material to carry out chlorination reaction with hydrochloric acid to prepare 5-chloro-2-pentanone. It can also be hydrogenated with 2-methylfuran to generate 2-methyl-4,5-dihydrofuran, and then ring-opened with hydrochloric acid and chlorinated to generate 5-chloro-2-pentanone. However, in these existing technologies, hydrochloric acid is used as the source of chlorination, wherein hydrochloric acid is rich in 70% water, and a large amount of high-chlorinated waste water ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C45/63C07C49/16
CPCC07C45/63C07C49/16
Inventor 王斌李勇刘吉红宋毅
Owner 淄博齐塑环保科技有限公司
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