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Green alga poly-saccharification nano-selenium and preparation method and application thereof

A green algae polysaccharide and nano-selenium technology, which is applied in the application, digestive system, pharmaceutical formulation and other directions, can solve the problems of nano-selenium size regulation stability, active molecule enrichment efficiency, etc. Effect

Active Publication Date: 2017-03-29
JINAN UNIVERSITY
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Problems solved by technology

Nano-selenium preparation technology and synergistic incorporation of active molecules are widely used in the research and development of related innovative medicines. At present, there are mainly problems such as nano-selenium size control, stability, and active molecule enrichment efficiency.

Method used

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  • Green alga poly-saccharification nano-selenium and preparation method and application thereof

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Embodiment 1

[0028]1) Preparation of nano-selenium modified by chlorophyll polysaccharide: under normal temperature and pressure, add sodium selenite solution to the aqueous solution of chlorophyll polysaccharide containing 10mg / mL, the final concentration of sodium selenite is 1mM, mix well, and then add dropwise to reduce Vitamin C solution, the final concentration of vitamin C is 4mM, mix evenly while adding dropwise, after constant volume, the red color that appears in the product will no longer deepen, and you can get functionalized nano-selenium sol (i.e. Chlorella polysaccharide nano-selenium ). The sol was dialyzed for 24 hours (molecular weight cut-off 8000kDa). The nanometer size of PSSNP was determined by observing the morphology of functionalized nano-selenium with a transmission electron microscope (TEM) and using a nanometer particle size analyzer. see results figure 1 -A and figure 1 -B is shown. The results show that the nano-selenium PSSNP selenium with regular shape, ...

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Abstract

The invention discloses green alga poly-saccharification nano-selenium and a preparation method and application thereof, and belongs to the technical field of the food biotechnology. The natural green alga poly-saccharification nano-selenium (PSSNP) prepared by the preparation method easily and conveniently is a necessary micronutrient for a human body, and polysaccharide has an immune regulation effect on an organism. The novel safe effective poly-saccharification nano-selenium is developed, and homogeneity of the nanometer size, stability of liquid-phase conservation and high efficiency of poly-saccharification are achieved. Green alga poly-saccharification nano-selenium (PSSNP) products are mainly suitable for auxiliary treating of enteritis and inflammatory bowel diseases and can also be applied to auxiliary preventing and treating of hyperlipidaemia, atherosclerosis, diabetes and other inflammation-related diseases; and the green alga poly-saccharification nano-selenium is convenient to use, green, safe and low in price and can alleviate patient pains and greatly reduce economical burden.

Description

technical field [0001] The invention belongs to the field of food biotechnology, and in particular relates to a chlorella polysaccharide nano-selenium and a preparation method and application thereof. Background technique [0002] Inflammatory bowel disease (Inflammation bowel disease, IBD) is a type of chronic recurrent inflammatory disease of the intestinal tract, among which ulcerative colitis (Ulcerative colitis, UC) and Crohn's disease (Crohn's Disease, CD) are the most common. In recent years, its incidence has gradually increased in my country, but traditional treatment mainly relies on steroid hormones and sulfasalazine (SASP), which has unsatisfactory curative effect, high recurrence rate, and many side effects. Relapse is also limited; thus IBD is considered as a clinically intractable disease, prone to relapse, often makes patients lose their ability to work and seriously affects the quality of life of patients. [0003] A major hallmark of inflammatory bowel dise...

Claims

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Application Information

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IPC IPC(8): A23L33/165A61K33/04A61P1/00A61P29/00A61P3/06A61P9/10A61P3/10A61K31/715
CPCA23V2002/00A61K31/715A61K33/04A23V2200/32A61K2300/00
Inventor 黄峙朱承慧凌钦婕
Owner JINAN UNIVERSITY
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