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Application of recombinant bovine basic fibroblast growth factor gel in repairing acne rosacea skin lesion

A technology of fibroblasts and growth factors, applied in the field of medicine

Active Publication Date: 2017-04-19
罗洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recombinant bovine basic fibroblast growth factor is used in wound repair, mainly for burn wounds, chronic wounds, fresh wounds, Parkinson's disease and other nervous system diseases and corneal damage repair, but it is used for rosacea skin lesions Repair not yet reported

Method used

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  • Application of recombinant bovine basic fibroblast growth factor gel in repairing acne rosacea skin lesion
  • Application of recombinant bovine basic fibroblast growth factor gel in repairing acne rosacea skin lesion
  • Application of recombinant bovine basic fibroblast growth factor gel in repairing acne rosacea skin lesion

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Experimental program
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Effect test

Embodiment Construction

[0026] The present invention is further elaborated below with clinical trial case:

[0027] From March 2015 to December 2015, 205 patients with papulopustular rosacea treated in the dermatology clinic of our hospital, including 151 females and 54 males, were randomly divided into two groups: recombinant bovine alkaline There were 103 people in the fibroblast growth factor repair group; 102 people in the blank group without repair. The repair group used recombinant bovine basic fibroblast growth factor gel to apply locally on the skin lesions, and the blank group did not use any external drugs, and the curative effect was observed after 2 weeks. The skin lesions of the patients in the repair group all improved to varying degrees, and the total effective rate was 82.35% to 98.33% (Table 1); the total effective rate of the patients in the blank group was 18.99% to 66.67% (Table 2). Index (Table 3), it can be seen that the use of recombinant bovine basic cell growth factor can si...

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Abstract

The invention relates to a new clinical application of a medicine, particularly to an application of recombinant bovine basic fibroblast growth factor gel in repairing acne rosacea skin lesion. The recombinant bovine basic fibroblast growth factor gel disclosed by the invention has a remarkable curative effect on acne rosacea, particularly on repairing erythema, dryness and furfuration. The invention provides a new method for repairing acne rosacea skin lesion, so that benefits are brought to many patients.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new application of a medicine, in particular to a medicine for repairing rosacea skin lesions and its clinical application. [0002] technical background [0003] Rosacea is a common chronic inflammatory skin disorder involving facial skin vessels and pilosebaceous glands. The occurrence of rosacea is related to heredity, destruction of skin barrier, nerve and immunity, and changes in blood vessels and lymphatic vessels. The pathological changes of rosacea vary with the stage of the disease. Erythema and telangiectasia mainly manifested as telangiectasia in the dermis and non-specific inflammatory infiltration around blood vessels. Diffuse inflammatory cell infiltration in the dermis can be seen in papular lesions, a large number of lymphocytes, a small amount of histiocytes and plasma cells around the hair follicles or sebaceous glands, epithelioid cells and macrophages can be seen in ...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/06A61P17/10A61P17/02
CPCA61K9/0014A61K9/06A61K38/1825
Inventor 罗洋孙玉姣栾秀丽张力
Owner 罗洋
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