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A pharmaceutical composition for treating renal hypertension

A technology of renal hypertension and drugs, which is applied in the field of medicine, can solve the problems of poor therapeutic effect of renal hypertension and achieve the effect of avoiding low blood pressure and mild blood pressure reduction effect

Inactive Publication Date: 2017-11-07
QINGDAO MUNICIPAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the medicines for the treatment of hypertension on the market are universal, and the specific treatment effect on renal hypertension is not good

Method used

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  • A pharmaceutical composition for treating renal hypertension
  • A pharmaceutical composition for treating renal hypertension
  • A pharmaceutical composition for treating renal hypertension

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0016] Test compound

[0017]

[0018] 1 HNMR (DMSO-d 6 )δppm 1.45-1.75(m,4H),1.96-2.14(m,2H),3.61(s,6H),4.18-4.33(m,2H),6.51-6.69(m,2H),7.16-7.38(m ,1H), 8.03(m,2H) and 8.60(s,2H)

[0019] MS ES + :411

[0020] The therapeutic effect of the medicine of the present invention on renal hypertension

[0021] The present invention takes hypertensive rats with two kidneys and one clip as the experimental object, and selects nitric oxide (NO) representing vasodilation factor and endothelin (ET) of vasoconstriction factor as indicators to study the hypotensive effect of the medicine of the present invention .

[0022] Establishment of Renal Hypertensive Rat Model

[0023] Male SD rats were adaptively fed for 3 days, and 10 of them were selected as the sham operation group, and the rest underwent unilateral renal artery ligation to establish an animal model with two kidneys and one clip. Rats were weighed, anesthetized by intraperitoneal injection of 10% chloral hydrate (3m...

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Abstract

The invention relates to a medicine composition for treating renal hypertension. The medicine composition is prepared from the following substances in parts by mass: 5 to 10 parts of compounds shown as the following formula, 10 to 20 parts of diluents, 1 to 3 parts of disintegrants and 1 to 5 parts of bonding agents. The formula is shown as the accompanying drawing.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating renal hypertension. Background technique [0002] Clinically, a systolic blood pressure higher than 140mmHg and a diastolic blood pressure higher than 90mmHg are generally defined as high blood pressure. Because hypertension is a chronic disease, it often causes lesions in important organs such as the heart, brain, and kidneys. In recent years, hypertension has become a major public health problem worldwide, and it tends to be younger. Renal hypertension is mainly due to elevated blood pressure caused by renal parenchymal lesions and renal artery lesions. It is called renal hypertension in symptomatic hypertension. At present, most of the medicines for treating hypertension on the market are universal, and the specific treatment effect on renal hypertension is not good. Contents of the invention [0003] The object of th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/505A61P9/12
CPCA61K31/505
Inventor 张树俭隋小妮
Owner QINGDAO MUNICIPAL HOSPITAL
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