A high-performance artificial intervertebral disc support and its preparation method

Abstract

The invention provides a preparation method of an artificial intervertebral disc with excellent mechanical properties and biocompatibility. The preparation method comprises the following steps: (1) PBST is melted, cooled, cut and polished into a PBST elliptical ring with smooth surface; (2) a PBST electrospun film is prepared and coiled for 6-10 layers, and an outer ring of the PBST elliptical ring obtained in the step (1) is tightly sleeved with the film; (3) chitosan hydrogel is prepared, and a hollow position in the elliptical ring formed by a product in the step (2) is filled with the chitosan hydrogel, wherein PBST is polybutylene-co-butylene succinate. The invention further provides the artificial intervertebral disc obtained with the method. The artificial intervertebral disc scaffold has excellent mechanical properties and good cytocompatibility, the compressive stress yield limit of the artificial intervertebral disc scaffold is 3.74 MPa, and the elasticity modulus is 29.93 Mpa; the tensile stress yield limit is 3.69 MPa, and the elasticity modulus is 43.18 Mpa.

Description

technical field [0001] The invention belongs to the field of tissue engineering, and in particular relates to an artificial intervertebral disc with excellent mechanical properties and biocompatibility and a preparation method. Background technique [0002] Low back pain is a common disease in spinal surgery, which affects the quality of life of patients and even leads to loss of working ability. Degenerative disc disease, mainly disc herniation, is the main cause of low back pain. With the development of my country's economy and the improvement of people's living standards, it is imminent to solve the low back pain caused by degenerative disc disease. [0003] At present, the clinical treatment of degenerative disc disease, whether it is drugs or physical therapy for the purpose of relieving symptoms, or surgical treatment for the purpose of restoring the stability of the vertebral body structure, has unsatisfactory results. Biotherapy strategies based on gene therapy, ce...

AI Technical Summary

Problems solved by technology

Although "Biomimetic method for combining the nucleus pulposus and annulus fibrosus for intervertebral disc tissue engineering" simulates the nucleus pulposus and the inner fibrosus, the mechanical properties of the obtained intervertebral disc scaffold are poor, and its elastic modulus is only about 250KPa

Also, it has not been clarified why the mechanical properties of the resulting scaffolds are higher compared to pure gel materials

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