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Method for extracting ginseng extract

An extraction method and ginseng extraction technology, which are applied in the fields of drug combination, pharmaceutical formula, food science, etc., can solve the problems of reducing the content of melanin and the rare extraction method of whitening effect components.

Active Publication Date: 2017-05-31
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although, there have been research reports on ginseng whitening active ingredients in the prior art, such as rare saponin F1 after transformation and rare saponin Rh6 and R4 in ginseng leaves reduce melanin content, and p-coumaric acid in ginseng leaves can inhibit tyrosine in vitro Enzyme activity, but studies on the extraction methods of these whitening active ingredients are rare

Method used

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  • Method for extracting ginseng extract
  • Method for extracting ginseng extract
  • Method for extracting ginseng extract

Examples

Experimental program
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Effect test

Embodiment 1

[0027] Take the dried ginseng root and cut it into small pieces, add deionized water at a ratio of 1:10 to soak overnight, heat to 100°C for extraction for 2 hours, extract 3 times, combine the supernatant, concentrate to 22°C when the relative density is 1.100, After cooling, use 75% ethanol for precipitation, collect the supernatant, remove the ethanol under reduced pressure, and dry to obtain the crude ginseng extract. Put the crude extract of ginseng into a vacuum oven at 40°C for thermal conversion for 72 hours. Reconvert the thermally converted ginseng crude extract with deionized water, add pretreated D101 macroporous resin, and elute with 10% ethanol until colorless, collect the eluate, and decompress Ethanol was removed and dried to obtain ginseng extract.

Embodiment 2

[0029] Take the dried ginseng root and cut it into small pieces, add deionized water at a ratio of 1:15 to soak overnight, heat to 100°C for extraction for 1 hour, extract twice, combine the supernatant, and concentrate to 18°C ​​when the relative density is 1.112, After cooling, use 75% ethanol for precipitation, collect the supernatant, remove the ethanol under reduced pressure, and dry to obtain the crude ginseng extract. Put the crude extract of ginseng into a vacuum oven at 50°C for thermal transformation for 48 hours. After reconverting the heat-converted ginseng crude extract, add pretreated D101 macroporous resin, elute with 40% ethanol until colorless, collect the eluate, remove ethanol under reduced pressure, and dry. Get ginseng extract.

Embodiment 3

[0031] Cut the dried fibrous roots of ginseng into small pieces, add deionized water to soak overnight at a ratio of 1:5, heat to 100°C for extraction for 3 hours, extract 3 times, combine the supernatant, and concentrate to 25°C when the relative density is 1.150, After cooling, use 75% ethanol for precipitation, collect the supernatant, remove the ethanol under reduced pressure, and dry to obtain the crude ginseng extract. Put the crude extract of ginseng into a vacuum oven at 60°C for thermal conversion for 48 hours. After reconverting the heat-converted ginseng crude extract, add pretreated AB8 macroporous resin, elute with 30% ethanol until colorless, collect the eluate, remove ethanol under reduced pressure, and dry , to obtain ginseng extract.

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Abstract

The invention relates to the field of plant extracts and application thereof, and in particular to a method for extracting ginseng extract. The method comprises the following steps: performing low-temperature thermal conversion on the crude ginseng extract subjected to water extraction and alcohol precipitation, redissolving, and performing D101 or AB8 type macroporous resin separation, thereby obtaining the ginseng extract. The experiment proves that the ginseng extract disclosed by the invention can achieve the effects of effectively inhibiting the activity of tyrosinase and obviously reducing the melanin content and has obvious effects of whitening and protecting skin, and the effects of whitening and protecting skin are obviously superior to those of a classic skin lightener arbutin.

Description

technical field [0001] The invention relates to plant extracts and application fields thereof, in particular to a method for extracting ginseng extracts. Background technique [0002] There are two types of melanin in human skin, pheomelanin and eumelanin. The former is brownish black, and the latter is reddish brown. The skin color is determined by the ratio of these two pigments. When the skin is irradiated by ultraviolet rays, the outermost keratinocytes, in order to protect the skin, produce melanin production stimulating factor (α-MSH) that binds to specific receptors in melanocytes, thereby starting a series of signal transduction pathways, and finally causing melanin synthesis The key enzyme-tyrosinase is synthesized, and then oxidizes tyrosine to generate dopa and dopaquinone, the precursor substances of melanin production. In the presence of cysteine / glutathione, dopaquinone generates cysteaminedopa and further oxidatively polymerizes to form soluble reddish-yellow...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/02A61K36/258A23L33/105A61P17/16
CPCA23V2002/00A61K8/97A61K36/258A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61Q19/02A23V2200/318A23V2250/2124
Inventor 萧伟孙立伟姜锐郭小莉赵祎武王振中
Owner JIANGSU KANION PHARMA CO LTD
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