Composition for repairing nasal mucosa, lowering anaphylactic reaction and resisting inflammation

A technology of allergic reaction and anti-inflammatory effect, applied in the direction of anti-inflammatory agent, drug combination, allergic diseases, etc., can solve the problem of nasal mucosa damage not playing a repairing role, etc., to reduce mucosal edema, high safety, reduce irritation Painful effects

Inactive Publication Date: 2017-05-31
JIANG SU PHARMAMAXCORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] All the nasal sprays currently on the market care for the nasal cavity by cleaning the nasal cavity to remove foreign matter in the nasal cavity, and have no repair effect on the damaged nasal mucosa.

Method used

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  • Composition for repairing nasal mucosa, lowering anaphylactic reaction and resisting inflammation
  • Composition for repairing nasal mucosa, lowering anaphylactic reaction and resisting inflammation
  • Composition for repairing nasal mucosa, lowering anaphylactic reaction and resisting inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] In the present embodiment, composition and content are as follows in the composition:

[0040] Material name Dosage (grams) α-keto acid pair 22 Sodium chloride 45 Benzalkonium chloride 1 0.1mol / l sodium hydroxide Adjust the pH value to pH=6 purified water Set the volume to 10000 grams

[0041] Preparation Process:

[0042] The α-keto acid molecular pair in this embodiment is a mixture of sodium pyruvate and ethyl pyruvate, and the mass ratio of sodium pyruvate and ethyl pyruvate is 3:1;

[0043] Slowly add the prescribed amount of α-ketoacid molecular pair and sodium chloride into 9500 grams of purified water, heat to 40-50°C and stir to dissolve, then cool down to 25-35°C, add the prescribed amount of benzalkonium chloride, and stir evenly. Use 0.1 mol / l sodium hydroxide to adjust the pH of the solution to 6, then use the remaining water to make up the volume to 10000 grams, filter and fill to obtain the product. The co...

Embodiment 2

[0045] In the present embodiment, composition and content are as follows in the composition:

[0046] Material name Dosage (grams) α-keto acid pair 22 Sodium chloride 45 polyhexamethylene biguanide 50 0.1mol / l sodium citrate Adjust the pH value to pH=6 purified water Set the volume to 10000 grams

[0047] Preparation Process:

[0048] The α-keto acid molecule pair in this embodiment is a mixture of potassium pyruvate and ethyl pyruvate, and the mass ratio of sodium pyruvate to ethyl pyruvate is 10:1;

[0049] Slowly add the prescribed amount of α-ketoacid molecular pair and sodium chloride into 9500 grams of purified water, heat to 40-50°C and stir to dissolve, cool down to 25-35°C, add the prescribed amount of polyhexamethylene biguanide, and stir Evenly, use 0.1 mol / l sodium citrate to adjust the pH of the solution to 6, then use the remaining water to make up the volume to 10000 grams, filter, and fill. The content of sodium p...

Embodiment 3

[0051] In the present embodiment, composition and content are as follows in the composition:

[0052] Material name Dosage (grams) α-keto acid pair 11 glucose 30 Benzalkonium chloride 25 0.1mol / l hydrochloric acid Adjust pH to pH=4.5 purified water Set the volume to 10000 grams

[0053] The α-keto acid molecule pair in this embodiment is a mixture of sodium pyruvate and ethyl pyruvate, and the mass ratio of sodium pyruvate and ethyl pyruvate is 12:1;

[0054] Slowly add the prescribed amount of α-ketoacid molecular pair and glucose into 9500 g of purified water, heat to 40-50°C and fully stir to dissolve, cool down to 25-35°C, add benzalkonium chloride, stir evenly, and use 0.1mol / l hydrochloric acid to adjust the pH of the solution to 4.5, then use the remaining water to make up the volume to 10,000 grams, filter, and fill. The content of sodium pyruvate in the preparation is 0.11%, and it is mainly used for repairing nasal muc...

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Abstract

The invention provides application of a composition containing alpha-ketonic acid to preparation of a medicine or a medical product for treating and repairing nasal mucosa and lowering anaphylactic reaction. The composition can be used for effectively removing pollutants in a nasal cavity, extraneous bacteria and viruses, allergens, pollen, various types of dust and harmful grains; accumulation of pathogenic factors on upper respiratory tracts of human is avoided or reduced. The composition has very high safety and does not have risks after being used for a long time; the composition is widely applied and disease-resisting and anti-allergy capabilities of the nasal cavity are easy to improve; meanwhile, the composition can be used for lowering the morbidity of various respiratory tract infectious diseases including cold, nasitis, nasosinusitis, nasopharyngitis and the like.

Description

technical field [0001] The invention relates to a composition for repairing nasal mucous membrane, reducing allergic reaction and anti-inflammatory effect, and belongs to the technical field of medical supplies. Background technique [0002] Breathing is the foundation of life. Breathing is completed by the upper respiratory tract and the lower respiratory tract. The nasal cavity, nasal sinuses and nasopharynx are the main components of the upper respiratory tract, and are the necessary places for the human body to exchange materials with nature. Sodium pyruvate is a normal component of all human and animal bodies, and is the basic metabolism of organisms. Sodium pyruvate has a significant protective effect on multi-cell and multi-organ functions, especially for important organs: heart, liver, brain and kidney. Blood / reperfusion injury is repaired, and there are no toxic side effects. At the same time, sodium pyruvate is an antioxidant and has a good effect on inhibiting inf...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K47/02A61K47/26A61K31/19A61K31/225A61K31/14A61K31/785A61P11/02A61P37/08A61P11/04A61P11/00A61P29/00
CPCA61K9/0043A61K9/12A61K31/14A61K31/19A61K31/225A61K31/785A61K47/02A61K47/26A61K2300/00
Inventor 蒋志君汪磊秦飞陆小娟
Owner JIANG SU PHARMAMAXCORP
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