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Preparation method for extracting medicinal and edible monomer for preventing and treating hyperuricemia and gout from coffee

A dual-use technology for hyperuricemia and medicine and food, which is applied in the direction of medical formula, food extraction, and the function of food ingredients, etc., can solve the problems of inconvenient use of traditional Chinese medicine, large dosage, and many adverse reactions of chemical drugs, etc. Low, easy to take, and the effect of reducing uric acid

Inactive Publication Date: 2017-05-31
广州中健中医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Aiming at the problems of many adverse reactions of chemical drugs in the above preparation method, inconvenient use of traditional Chinese medicine and large dosage, the present invention provides a drug for preventing and treating hyperuricemia and gout that is extracted from coffee with small dosage, convenient use and few adverse reactions. Preparation method of food dual-purpose monomer

Method used

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  • Preparation method for extracting medicinal and edible monomer for preventing and treating hyperuricemia and gout from coffee
  • Preparation method for extracting medicinal and edible monomer for preventing and treating hyperuricemia and gout from coffee

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1, the capsule prepared by the present invention

[0022] 1) Weigh the raw coffee beans, break the seed coat, and some 3# empty capsule shells are for later use;

[0023] 2) Add 10 times the amount of water to the raw material and boil for 1 hour, filter while hot, add 20 times the amount of 70% ethanol to the residue and extract it twice by heating and refluxing for 2 hours each time, combine the two extracts, recover the ethanol under reduced pressure, and add ammonia water to adjust the extract. The pH value reached 9, stirred, allowed to cool, and concentrated by high-speed centrifugation to obtain the filtrate. The pH of the filtrate was adjusted to neutrality with hydrochloric acid, applied to an AB-8 macroporous resin column, statically adsorbed for 2 hours, eluted with 10BV water, and discarded. Then use different concentrations of ethanol to elute in order from low to high, use thin-layer chromatography to identify whether the eluent contains a monom...

Embodiment 2

[0024] Example 2, the tablet prepared by the present invention

[0025] 1) Weigh the raw coffee beans and break the seed coat;

[0026] 2) Add 10 times the amount of water to the raw material and boil for 1 hour, filter while hot, add 20 times the amount of 70% ethanol to the residue and extract it twice by heating and refluxing for 2 hours each time, combine the two extracts, recover the ethanol under reduced pressure, and add ammonia water to adjust the extract. The pH value reached 9, stirred, allowed to cool, and concentrated by high-speed centrifugation to obtain the filtrate. The pH of the filtrate was adjusted to neutrality with hydrochloric acid, applied to an AB-8 macroporous resin column, statically adsorbed for 2 hours, eluted with 10BV water, and discarded. Then use different concentrations of ethanol to elute in order from low to high, use thin-layer chromatography to identify whether the eluent contains a monomer in the monomer compound group and its relative con...

Embodiment 3

[0027] Example 3. Preparation of mixture based on invention

[0028] 1) Weigh the raw coffee beans, break the seed coat, and use a 10mL / support oral liquid vial for subsequent use;

[0029] 2) Add 10 times the amount of water to the raw material and boil for 1 hour, filter while hot, add 20 times the amount of 70% ethanol to the residue and extract it twice by heating and refluxing for 2 hours each time, combine the two extracts, recover the ethanol under reduced pressure, and add ammonia water to adjust the extract. The pH value reached 9, stirred, allowed to cool, and concentrated by high-speed centrifugation to obtain the filtrate. The pH of the filtrate was adjusted to neutrality with hydrochloric acid, applied to an AB-8 macroporous resin column, statically adsorbed for 2 hours, eluted with 10BV water, and discarded. Then use different concentrations of ethanol to elute in order from low to high, use thin-layer chromatography to identify whether the eluent contains a mono...

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Abstract

The invention relates to a preparation method for extracting a medicinal and edible monomer for preventing and treating hyperuricemia and gout from coffee. The method comprises the following steps: breaking seed coats of the raw material coffee, adding water, boiling, filtering while the liquid is hot, adding ethanol into the residues, extracting under reflux, regulating the pH value of the extracting solution to 9, carrying out high-speed centrifugal concentration to obtain a filtrate, regulating the pH value of the filtrate to neutrality, passing through an AB-8 macroporous resin column, sequentially eluting with ethanols with gradually increasing concentrations, identifying by thin-layer chromatography, collecting the eluates with high proportion of the target compound, merging, and making the obtained eluate into the product. The coffee contains chlorogenic acid, caffeoyl quinic acid, dicaffeoyl quinic acid which can effectively lower uric acid, and thus, has application potential in treating hyperuricemia and gout in clinic. The method purposefully enriches the target monomer, has the advantages of low cost and high yield, and can easily implement industrialized large-scale production. Capsules, tablets, health protection tea and other preparation formulations prepared from the monomer are convenient to take in many different ways.

Description

technical field [0001] The invention particularly relates to a preparation method of a medicine and food monomer extracted from coffee for preventing and treating hyperuricemia and gout. Background technique [0002] After the 1980s, with the improvement of economic and living standards, dietary structure and living habits have changed, resulting in an increasing trend of the incidence of hyperuricemia and gout. In terms of epidemiology, the incidence of hyperuricemia varies with ethnicity and region, and reports from different countries are inconsistent. In my country, the incidence of gout is 0.26% to 0.34%, and the incidence of hyperuricemia is 5.78% to 13.8%. %, hyperuricemia associated with gout has also become one of the important risk factors for coronary heart disease and hypertension. (Abbott RD, Brand FN, KannelWB, Castelli WP. Gout coronary heart disease: the Framingham Study[J]. J Clin Epidemiol, 1988, 41(3): 237-242. Johan Sundstrom, Lisa Sullivan, Ralph B. Dagos...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/48A61K9/36A61K9/08A23L33/105A23F3/34A61P19/06
CPCA23F3/34A23V2002/00A61K9/0053A61K9/08A61K9/1623A61K9/2059A61K9/2826A61K36/74A61K2236/331A61K2236/333A61K2236/39A61K2236/55A23V2200/30A23V2250/2108A23V2300/14
Inventor 张清仲
Owner 广州中健中医药科技有限公司
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