Preparation method and application of immune enhancer based on ganoderma lucidum and astragalus membranaceus fermentation substance

Abstract

The invention discloses a preparation method and application of an immune enhancer based on a ganoderma lucidum and astragalus membranaceus dreg bidirectional solid fermentation compound, and belongs to the technical field of medicines. A fermentation substrate is prepared from astragalus membranaceus dregs, a ganoderma lucidum strain is inoculated into the fermentation substrate for culture in a 25 DEG C constant temperature fermentation chamber, the time when mycelia grow all over a bottle is recorded as 0 day, 25 days after the fermentation is terminated, and the whole bottle of fermentation products are collected, and frozen-dried to obtain the ganoderma lucidum and astragalus membranaceus fermentation substance. The ganoderma lucidum and astragalus membranaceus fermentation substance is prepared into immune enhancers in any solid dosage forms such as granules, tablets and capsules by traditional Chinese medicine preparation technology and process in the prior art, the water solubility of 40% ethanol eluent of the ganoderma lucidum and astragalus membranaceus fermentation substance is excellent, the ganoderma lucidum and astragalus membranaceus fermentation substance also can be prepared into an oral liquid or other liquid dosage forms except the solid dosage forms. The astragalus membranaceus dreg can be rationally developed and used by the bidirectional solid fermentation technology, waste is turned into treasure, the ganoderma lucidum and astragalus membranaceus fermentation substance is prepared into functional food and medicines for enhancing the immunity of the human body, and the ganoderma lucidum and astragalus membranaceus fermentation substance has very good application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method and application of an immune enhancer based on Zhiqi fungus. Background technique [0002] The two-way solid fermentation technology is to form a fermentation combination of medicinal fungal fermentation strains (such as Ganoderma lucidum, Huaier, Agaricus, etc.) and fermentation substrates (Chinese medicinal materials or medicinal residues with certain active ingredients). Conditions for solid fermentation. Zhiqi fungus is a fermentation complex of ganoderma mycelium and astragalus dregs obtained by inoculating ganoderma strains in astragalus dregs for solid fermentation. On the one hand, the chemical components of Astragalus dregs in the medium provide nutrition for the growth of Ganoderma lucidum fungus, and on the other hand, the enzymes of Ganoderma lucidum fungi can change the tissue and components of Astragalus dregs, so it has bidirectio...

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Problems solved by technology

[0004] At present, there is no report on the preparation of immune enhancer by using Ganoderma lucidum-Astragalus dregs two-way solid fermentation compound. Among them, Chinese patent 200810156224.6 discloses a 6-O-β-D-glucosyl-3,6,16, The preparation method of 25-tetrahydroxycyclopine, which also adopts the two-way solid fermentation technology of ganoderma lucidum and astragalus dregs, but it is different from the fermentation method of this patent, and also different from the processing method of the fermentation product of this patent The same, and the invention purpose of this patent is also different

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