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A chitosan-containing curcumin sustained-release aggregate and preparation method thereof

A technology of curcumin and chitosan, which is applied in the directions of inactive medical preparations, pharmaceutical formulations, antibacterial drugs, etc., can solve the problems of unfavorable curcumin slow release, poor stability, poor curcumin slow release effect, etc. Achieve stable liquid crystal structure, reduce waste, and achieve the effect of targeted release

Active Publication Date: 2019-09-24
海生健康科技(青岛)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Due to the specificity of the curcumin structure, the drug-loaded body prepared by using chitosan or Tween as the raw material has poor structural stability, which makes the slow-release effect of the drug-loaded body on curcumin poor, which is not conducive to the slow release of curcumin. freed

Method used

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  • A chitosan-containing curcumin sustained-release aggregate and preparation method thereof
  • A chitosan-containing curcumin sustained-release aggregate and preparation method thereof
  • A chitosan-containing curcumin sustained-release aggregate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Weigh 1.98g of Tween 80 and 0.275g of ethyl oleate and place them in a clean 10mL colorimetric tube, then weigh 0.0075g of curcumin and place them in the mixture of Tween 80 and ethyl oleate, put them in a magnetic Use a magnetic stirrer to stir for 2.5 hours, and control the temperature of the water bath to 25°C to ensure that the curcumin is fully dissolved in the mixture of the surfactant and the oil phase. Then add 0.495g of water-soluble chitosan and 2.25g of water, use a quick mixer to mix evenly, control the temperature at 60°C, and centrifugally stir until the sample is completely dissolved, and use a centrifuge to keep the speed at 3500r / min to remove air bubbles in the sample , so as to obtain curcumin sustained-release drug-loaded aggregates containing chitosan, denoted as E 2 C 3 .

[0054] In this embodiment, the mass ratio of Tween 80, water-soluble chitosan, ethyl oleate and water is 39.6:9.9:5.5:45.

Embodiment 2

[0056] This embodiment is the same as Example 1, except that the mass ratio of Tween 80, water-soluble chitosan, ethyl oleate and water in this embodiment is 47.0:5.2:2.8:45, and the prepared shell-containing Curcumin slow-release drug-loaded aggregates of glycans, denoted as E 1 C 1 .

Embodiment 3

[0058] This embodiment is the same as Example 1, except that the mass ratio of Tween 80, water-soluble chitosan, ethyl oleate and water in this embodiment is 44.5:5.0:5.5:45, and the prepared shell-containing Curcumin slow-release drug-loaded aggregates of glycans, denoted as E 2 C 1 .

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Abstract

The invention discloses chitosan-containing curcumin slow-release aggregate and a preparation method thereof; the chitosan-containing curcumin slow-release aggregate comprises transparent immobile liquid crystal; the liquid crystal comprises a surfactant, ethyl oleate and water at a mass ratio of (34-56):(1-14):(38-57), wherein the surfactant is a mixture of tween-80 and water-soluble chitosan, and the mass ratio of the tween-80 to the water-soluble chitosan is (4-9):1; the liquid crystal is coated with curcumin; the curcumin has a concentration of 0.7-2.5 mg / g in the liquid crystal. The chitosan-containing curcumin slow-release aggregate has good structural stability, has improved curcumin slow-release effect and allows the curcumin to be present and released continuously and stably.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a chitosan-containing slow-release drug-loaded curcumin aggregate and a preparation method. Background technique [0002] Curcumin is a diketone plant extract compound, which has various biological and medical effects, such as anti-oxidation, anti-inflammatory, antibacterial and anti-cancer effects, so it has a wide range of application prospects in medicine. However, due to the poor water solubility of curcumin, it is unstable to light and heat, and it is easily oxidized, which limits the practical application of curcumin. Therefore, in order to utilize the biological activity of curcumin more effectively, it is very necessary to construct an appropriate delivery system. [0003] Chitosan (CS, β-(1-4)-2-acetylamino-2-deoxy-D-glucose) is the product of chitin deacetylation, and it is the only positively charged basic polysaccharide among natural polysaccharides. Its r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/52A61K31/12A61K47/36A61K47/26A61K47/14A61P39/06A61P29/00A61P31/04A61P35/00
Inventor 王仲妮李扬张丽
Owner 海生健康科技(青岛)有限公司
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