Method for detection of allergen flavor substances as forbidden and limited substances in cosmetics

Abstract

The invention relates to the technical field of compound detection and particularly relates to a method for detection of allergen flavor substances as forbidden and limited substances in cosmetics. The method comprises taking a cosmetic sample, preparing a sample solution, detecting allergen flavor substances as forbidden and limited substances in the sample solution through liquid chromatography-mass spectrometry, wherein liquid chromatography conditions comprise a phenyl column as a chromatographic column, RP-MS or C18 chromatographic column, acetonitrile as a mobile phase A, 0.05% formic acid solution containing 5 mM of ammonium acetate as a mobile phase B, gradient elution is used, and mass spectrometry conditions comprise an electrospray ion source, positive ion scanning, multiple reaction monitoring, an ion source temperature of 650 DEG C and ion source voltage of 5500V. The method has advantages of low detection limit, high detection efficiency, good recovery rate and qualitative and quantitative treatment synchronization. The method can be used for rapid screening of common flavor substance allergic chemicals in cosmetics so as to meet the current enterprise quality control, market supervision and consumer safety protection requirements.

Description

technical field [0001] The invention relates to the technical field of compound detection, in particular to a detection method for prohibited and restricted allergen fragrance substances in cosmetics. Background technique [0002] With the continuous development of my country's reform and opening up, the economic level and quality of life of the people in our country are also constantly improving, and the aesthetic concept is constantly changing. Cosmetics have become a part of people's daily consumption and are also necessities of life. According to statistics, in 2014, the annual sales of cosmetics in my country reached more than 200 billion yuan, accounting for about 8.8% of the global cosmetics market, second only to the United States, and China has become one of the largest cosmetics markets in the world. According to statistics, an average woman uses 12 personal care products every day, containing 168 ingredients; an average man uses 6 personal care products every day,...

AI Technical Summary

Problems solved by technology

However, due to the complex ingredients of cosmetics, many aromatic and volatile substances, various dosage forms, and various types, and there are many additives and functional ingredients such as emulsifiers, lubricants, and surfactants, when gas chromatography or gas chromatography-mass spectrometry The interference is large, the baseline is high, and the analysis time is 30 to 40 minutes. However, liquid chromatography analysis also has the problems of long analysis time, low peak separation, and inaccurate qualitative determination. Therefore, these methods have certain limitations.

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