Biodegradable poly-HPMA-Gd magnetic resonance imaging probe and preparing method thereof

A magnetic resonance imaging and biodegradation technology, applied in the field of medical imaging, can solve problems such as difficult to achieve satisfactory imaging effects, low sensitivity and non-specificity, achieve high-efficiency biocompatibility, increase aggregation, and increase passive targeting The effect of the ability

Active Publication Date: 2017-06-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, they all belong to small molecular magnetic resonance imaging probes, which have disadvantages such as low sensitivity, non-specificity, and rapid clearance from the body; and they mainly pass passive diffusion into the tumor stroma or tissue stroma, making it difficult to achieve satisfactory results. Imaging effect

Method used

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  • Biodegradable poly-HPMA-Gd magnetic resonance imaging probe and preparing method thereof
  • Biodegradable poly-HPMA-Gd magnetic resonance imaging probe and preparing method thereof
  • Biodegradable poly-HPMA-Gd magnetic resonance imaging probe and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A biodegradable polymeric HPMA-Gd magnetic resonance imaging probe, the chain structure is as follows:

[0043]

[0044] Among them: m:n:o=35~45:410~450:65~70;

[0045]

[0046] The order of the C, B and A groups in the system is not fixed, and the R group can be connected to any one of C, B and A.

Embodiment 2

[0048] On the basis of embodiment 1:

[0049] Wherein, R1 is SH, m:n:o=35:410:65.

[0050] The average molecular weight of the magnetic resonance imaging probe is 85KDa.

Embodiment 3

[0052] On the basis of embodiment 1:

[0053] Wherein, R1 is not SH, m:n:o=45:450:70.

[0054] The average molecular weight of the magnetic resonance imaging probe is 94KDa.

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Abstract

The invention provides a biodegradable poly-HPMA-Gd magnetic resonance imaging (MRI) probe used for inserting enzyme sensitive polypeptide GFLG into a poly-HPMA backbone structure. The molecular weight of a prepared polymer is basically controllable, the molecular weight is high, and the dispersion coefficient (PDI) is low; and linear HPMA-DOTA-Gd is obtained through coupling with Gd(III). The probe is an efficient nanoscale MRI probe with biocompatibility, and can be used for clinical tumor diagnosis and adjuvant therapy.

Description

technical field [0001] The invention belongs to the technical field of medical imaging, and relates to a polymer magnetic resonance imaging probe, in particular to a biodegradable polymeric HPMA-Gd magnetic resonance imaging probe. Background technique [0002] Due to the advantages of high spatial resolution, 3D image information and no radioactivity, magnetic resonance imaging (MRI) has become an effective non-invasive diagnosis method for tumors. According to incomplete statistics, more than 50% of clinical MRI tumor diagnosis requires the use of MRI magnetic resonance imaging probes. Commonly used clinical MRI magnetic resonance imaging probes include gadoterate meglumine (Magnevist) and gadoterate meglumine (Dotarem). However, they all belong to small molecular magnetic resonance imaging probes, which have the disadvantages of low sensitivity, non-specificity, and rapid clearance from the body; and they mainly pass passive diffusion into the tumor stroma or tissue stro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/14A61K49/18
Inventor 罗奎龚启勇
Owner SICHUAN UNIV
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