Unlock instant, AI-driven research and patent intelligence for your innovation.
Protein markers for auxiliary diagnosis of severe secondary pulmonary tuberculosis
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A tuberculosis, secondary technology, applied in the field of protein markers for the auxiliary diagnosis of severe secondary tuberculosis, can solve the problems of aggravating protein markers, unclear factors or mechanisms of development and prognosis, and aggravating pathophysiological mechanisms
Active Publication Date: 2018-10-02
BEIJING CHEST HOSPITAL CAPITAL MEDICAL UNIV
View PDF5 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
Although great progress has been made in research on the pathogenesis of tuberculosis in recent years, the pathophysiological mechanism of further aggravation, factors or mechanisms affecting its occurrence, development and prognosis are still unclear
There is currently a lack of protein markers for early warning of the progression and exacerbation of secondary pulmonary tuberculosis
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0077] Example 1, Screening of protein markers
[0078] 1. Research object
[0079] The peripheral blood plasma samples of 6 patients diagnosed with secondary pulmonary tuberculosis from March 2015 to December 2015 in Beijing Chest Hospital Affiliated to Capital Medical University were collected. Among them, there were 3 cases of severe secondary pulmonary tuberculosis, 2 males and 1 female, with an average age of 51.33±16.66 years. There were 3 cases of mild secondary pulmonary tuberculosis, 2 males and 1 female, with an average age of 52.67±22.82 years. The informed consent protocol and research procedures were approved by the ethics committee, and all patients and healthy volunteers who agreed to participate in this study signed an informed consent form.
[0080] 2. Screen protein markers
[0081] The peripheral blood plasma samples of the research subjects were taken, proteins were extracted, and the differentially expressed proteins were screened for the severe seconda...
Embodiment 2
[0086] Embodiment 2, establishment and verification of diagnostic model
[0087] 1. Selection and grouping of research objects
[0088] Collected peripheral blood plasma samples from 143 cases of patients diagnosed with secondary pulmonary tuberculosis in Beijing Chest Hospital Affiliated to Capital Medical University from March 2015 to December 2015. The patients were divided into severe secondary pulmonary tuberculosis group with 72 cases and mild secondary There were 71 cases in the pulmonary tuberculosis group. The informed consent protocol and research procedures were approved by the ethics committee, and all patients and healthy volunteers who agreed to participate in this study signed an informed consent form.
[0089] 2. Elisa detection
[0090] The peripheral blood plasma samples collected in step 1 were taken, and the concentrations of SOD1, S100A9, ORM2, and IL1F6 in plasma were detected using SOD1 Elisa kit, S100A9 Elisa kit, ORM2 Elisa kit, and IL1F6 Elisa kit, ...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
concentration
aaaaa
aaaaa
concentration
aaaaa
aaaaa
Login to View More
Abstract
The invention discloses protein markers assisting diagnosis of severe secondary pulmonary tuberculosis. The invention provides applications of a product for detecting SOD1 protein, a product for detecting S100A9 protein, a product for detecting ORM2 protein and a product for detecting IL1F6 protein in preparation of a kit used for assisting diagnosis of severe secondary pulmonary tuberculosis. The four protein markers (S100A9, ORM2, IL1F6 and SOD1) assisting diagnosis of the severe secondary pulmonary tuberculosis are found, and a model for assisting diagnosis of the severe secondary pulmonary tuberculosis by utilizing the four protein markers is built. The protein markers provide basis for further explanation of developing and aggravating mechanisms of the secondary pulmonary tuberculosis, provide a novel method and novel indexes for disease development, aggravation early warning, and forecast evaluation, lays a foundation for reasonable treatment and cure of the severe secondary pulmonary tuberculosis, and provides technical supports for reducing the death rate of pulmonary tuberculosis.
Description
technical field [0001] The invention relates to a protein marker for auxiliary diagnosis of severe secondary pulmonary tuberculosis. Background technique [0002] Tuberculosis remains one of the deadliest infectious diseases of worldwide concern. If it develops into severe secondary pulmonary tuberculosis, the hospitalization time will be long, the hospitalization fee will be high, the mortality rate will increase, and a large amount of medical resources will be consumed. The mechanism of disease progression, exacerbation, and death in patients with secondary pulmonary tuberculosis is relatively complex, involving various mechanisms such as etiology, molecular biology, immune regulation, therapeutic drugs, underlying diseases, nutritional status, and social economy. Although the research on the pathogenesis of tuberculosis has made great progress in recent years, the pathophysiological mechanism of its further aggravation, the factors or mechanisms affecting its occurrence,...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More