Method for detecting learning, memory and cognitive function of rat based on neuronal oscillatory activity

A technology of learning, memory and cognitive function, which is applied in the field of detecting learning, memory and cognitive function of rats based on neural oscillation activity, and can solve the problems that cannot be carried out in animals, and the behavioral test has a very large impact.

Inactive Publication Date: 2017-07-21
TIANJIN UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

Among them, the state of experimental animals and the conditions of the experimental environment have a great influence on the results of behavioral experiments; the development of biochemical experiments requires a lot of consumables, and cannot be carried out in animals.

Method used

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  • Method for detecting learning, memory and cognitive function of rat based on neuronal oscillatory activity
  • Method for detecting learning, memory and cognitive function of rat based on neuronal oscillatory activity
  • Method for detecting learning, memory and cognitive function of rat based on neuronal oscillatory activity

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Embodiment 1

[0025] A method for detecting learning, memory and cognitive functions in rats based on neural oscillation activity, see figure 1 , the method includes the following steps:

[0026] 101: first collect the LFPs signal, and then filter and denoise the LFPs signal to extract theta rhythm and gamma rhythm;

[0027] 102: Calculation of the coupling relationship of nerve rhythms, including calculation of nerve rhythms in the same brain region and calculation of nerve rhythms in different brain regions; use the calculated nerve rhythms as characteristic parameters;

[0028] 103: Statistical analysis is performed on the extracted characteristic parameters, so as to realize the exploration of the protective mechanism of learning, memory and cognitive function of rats.

[0029] In summary, the embodiment of the present invention proceeds from the level of mesoscopic electrophysiological information through the above steps 101 to 103, by recording the local field potentials of the CA1 a...

Embodiment 2

[0031] Combined with specific calculation formulas, examples and attached figure 2 The scheme in Example 1 is further introduced, see the following description for details:

[0032] 201: signal collection;

[0033] Rats were anesthetized by intraperitoneal injection of urethane (3.5ml / kg). After confirming that the rat was under anesthesia, it was fixed in a stereotaxic apparatus. An electric blanket was placed under the body of the rat to keep the body temperature of the rat at 37°C. Expose the skull, observe with a microscope, determine the position of the bregma, and preliminarily determine the positions of the CA1 and CA3 brain regions (CA1 brain region: posterior 2.5mm, lateral opening 2.5mm, subcortical 2mm; CA3 brain region: posterior 4.2mm, 3.5mm laterally and 2.5mm below the cortex), above which a small hole with a diameter of 8mm was drilled with a dental drill to expose the cerebral cortex.

[0034] Turn on the electrophysiological recording instrument, and the...

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Abstract

The invention discloses a method for detecting learning, memory and cognitive function of a rat based on a neuronal oscillatory activity. The method comprises the following steps: collecting the LFPs signal, filtering and denoising the LFPs signal, and extracting the theta rhythm and the gamma rhythm from the LFPs signal; calculating the coupling relationship of the neural rhythm, including calculating the neural rhythm of the rhythm in the same brain region and different brain regions; taking the calculated neural rhythm as a characteristic parameter; statistically analyzing the extracted characteristic parameter so as to achieve the detection of the learning, memory and cognitive function of the rat. According to the method, a device for collecting local field potential of the rat is constructed; the LFPs of the hippocampal CA1 and CA3 brain regions of the rat are collected; the signal is analyzed in time domain and frequency domain and the like; and then the learning, memory and cognitive function of the rat are reflected by analyzing the cross coupling between the theta rhythm and the gamma rhythm.

Description

technical field [0001] The invention relates to the field of neural computing, in particular to a method for detecting learning, memory and cognitive functions of rats based on neural oscillation activities. Background technique [0002] Since the beginning of consciousness, human beings have begun to study the brain. In 2013, the United States even proposed the "Promoting Innovative Neurotechnology Brain Research Project", referred to as "Brain Project". It aims to explore the working mechanism of the human brain, map brain activity, and ultimately develop methods for brain diseases. The Human Brain Project includes research on the combination of neuroscience and informatics. In neuroscience research, the most commonly used animal models are rats and mice, which can exhibit various behaviors related to human diseases. [0003] In the study of rat models, the most commonly used behavioral testing methods include the Morris water maze, Barnes maze, and eight-arm maze for st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/0476A61B5/00G06F19/00
CPCA61B5/40A61B5/4088A61B5/6868A61B5/7203A61B5/7235A61B2503/40A61B2503/42A61B5/316A61B5/369G16H50/20
Inventor 王玲杨佳佳明东王发颀许敏鹏
Owner TIANJIN UNIV
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