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Method for detecting influence of transcranial magnetic stimulation on working memory based on Granger causality

A technology of transcranial magnetic stimulation and working memory, applied in magnetic therapy, electrotherapy, diagnostic recording/measurement, etc., can solve problems such as difficulties and achieve the effect of improving the effect

Inactive Publication Date: 2021-07-09
HEBEI UNIV OF TECH
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Problems solved by technology

[0004] However, the prior art has not studied the effects of the above-mentioned different modes of transcranial magnetic stimulation on working memory, which brings difficulties for choosing the mode of transcranial magnetic stimulation to improve working memory impairment

Method used

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  • Method for detecting influence of transcranial magnetic stimulation on working memory based on Granger causality
  • Method for detecting influence of transcranial magnetic stimulation on working memory based on Granger causality
  • Method for detecting influence of transcranial magnetic stimulation on working memory based on Granger causality

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Embodiment

[0038] In this example, rats are used as the target object to illustrate the method for detecting the influence of transcranial magnetic stimulation on working memory based on Granger causality, including the following steps:

[0039] The first step is to apply transcranial magnetic stimulation to rats, and implant microelectrodes in the prefrontal brain area of ​​rats;

[0040] A number of rats were divided into four groups, namely blank group, rTMS group, cTBS group and iTBS group; the rTMS group was given high-frequency repetitive transcranial magnetic stimulation (rTMS for short) with a frequency of 5 Hz; the cTBS group was given continuous theta rhythm Stimulation (cTBS for short), the iTBS group was given intermittent theta rhythmic stimulation (iTBS for short), the pulses of cTBS and iTBS were released in the form of clusters, the inter-cluster frequency was 5 Hz, and the intra-cluster frequency was 50 Hz, cTBS continuously delivered cluster stimulation , iTBS stimulati...

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Abstract

The invention relates to a method for detecting the influence of transcranial magnetic stimulation on working memory based on Granger causality, which comprises the following steps of: 1, performing transcranial magnetic stimulation on a target object, and implanting a microelectrode into the head of the target object; 2, enabling the target object to execute a T-maze behavioral task, collecting a local field potential signal of a prefrontal cortex layer of the target object through a microelectrode, preprocessing the local field potential signal, and extracting a gamma frequency band; 3, employing a Granger causal algorithm to calculate GC values between the microelectrode channels in the gamma frequency band, by using the GC values as characteristic parameters, constructing a Granger causal network, wherein the size of the GC values and the Granger causal density of the Granger causal network reflect the influence of transcranial magnetic stimulation on the working memory of the target object. According to the method, a local field potential signal of a prefrontal cortex of a target object is collected, and the Granger causality of a neural rhythm is analyzed, so that the working memory and cognitive functions of the target object are reflected.

Description

technical field [0001] The invention relates to the technical field of nerve stimulation, in particular to a method for detecting the influence of transcranial magnetic stimulation on working memory based on Granger causality, which is used to detect the influence of different modes of transcranial magnetic stimulation on the working memory of a target object. Background technique [0002] Transcranial magnetic stimulation (TMS) is a non-invasive neuromodulation technology, which has been widely concerned and applied in the exploration of advanced cognitive functions of the brain and the clinical field of neuropsychiatric diseases. Transcranial magnetic stimulation technology can stimulate specific cerebral cortex by regulating the excitability of neurons, thereby improving the working memory function of normal subjects and patients with impaired memory function. [0003] High-frequency repetitive transcranial magnetic stimulation (rTMS) can stimulate the cerebral cortex and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61N2/00
CPCA61B5/4088A61N2/006
Inventor 郭苗苗吉利辉徐桂芝王中豪张天恒
Owner HEBEI UNIV OF TECH
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