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Silica-gel scar removing and repairing product containing hyaluronic acid and antibacterial peptide and preparation method thereof

A silicone gel technology for removing scars and hyaluronic acid, which is applied to medical preparations containing active ingredients, local antibacterial agents, and medical preparations with no active ingredients, etc. It can solve the problem of poor moisturizing and hydration effects, skin redness, and depression. The antibacterial effect needs to be improved to achieve good chemical stability and physiological inertia, strong antibacterial and anti-inflammatory effects, and strong moisturizing and hydrating effects

Inactive Publication Date: 2017-07-21
国械(上海)贸易有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has a certain antibacterial effect, but the moisturizing and hydration effects are poor, and discomfort symptoms such as skin redness, allergies, itching, and tightness will appear during use
Chinese invention patent application (patent application number 201510503456.4) discloses a "hyaluronic acid silicone gel composition and preparation method for preventing scar formation and early repair", which introduces hyaluronic acid components and onions into traditional silicone gel products extract, which greatly improves the moisturizing and hydration effects of silicone gel products, but its antibacterial effect needs to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A silicone gel scar-removing and repairing product containing hyaluronic acid and antibacterial peptides, including the following raw materials by weight: 0.5 parts of antibacterial peptides, 100 parts of polydimethylsiloxane, and 100 parts of polydimethylsiloxane cross-linked polymer Parts, 10 parts of hyaluronic acid, 4 parts of carbomer, 5 parts of triethanolamine, 100 parts of glycerol and 420 parts of purified water;

[0014] Preparation method: In the first step, add 140 parts of purified water to hyaluronic acid and stir to make a hyaluronic acid solution; in the second step, add 140 parts of purified water to the antimicrobial peptide and stir evenly to make an antimicrobial peptide solution; Step: First add carbomer to glycerol and stir. After dissolving, add 140 parts of purified water and stir evenly, let stand for more than 4 hours, then add triethanolamine to adjust the pH to 6.5 to make carbomer solution ; The fourth step, sequentially add the hyaluronic acid...

Embodiment 2

[0016] A silicone gel scar-removing and repairing product containing hyaluronic acid and antibacterial peptides, comprising the following parts by weight of raw materials: 10 parts of antibacterial peptides, 200 parts of polydimethylsiloxane, and 200 parts of polydimethylsiloxane cross-linked polymer Parts, 50 parts of hyaluronic acid, 6 parts of carbomer, 8 parts of triethanolamine, 150 parts of glycerol and 480 parts of purified water;

[0017] Preparation method: In the first step, add 160 parts of purified water to hyaluronic acid and stir to make a hyaluronic acid solution; in the second step, add 160 parts of purified water to the antimicrobial peptide and stir evenly to make an antimicrobial peptide solution; Step, first add carbomer to glycerol and stir, after dissolving, add 160 parts of purified water and stir evenly, let stand for more than 4 hours, and then add triethanolamine to adjust the pH to 7.2 to make carbomer solution ; The fourth step, sequentially add the hy...

Embodiment 3

[0019] A silicone gel scar-removing and repairing product containing hyaluronic acid and antibacterial peptides, comprising the following parts by weight of raw materials: 5 parts of antibacterial peptides, 150 parts of polydimethylsiloxane, and 150 parts of polydimethylsiloxane cross-linked polymer Parts, 25 parts of hyaluronic acid, 5 parts of carbomer, 5 parts of triethanolamine, 100 parts of glycerol and 600 parts of purified water;

[0020] Preparation method: the first step is to add 200 parts of purified water to hyaluronic acid and stir to make a hyaluronic acid solution; in the second step, another 200 parts of purified water is added to the antimicrobial peptide and stir evenly to make an antimicrobial peptide solution; Step: First add carbomer to glycerol and stir, after dissolving, add 200 parts of purified water and stir evenly, let stand for more than 4 hours, then add triethanolamine to adjust the pH to 7.0 to make carbomer solution ; The fourth step, sequentially ...

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PUM

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Abstract

The invention discloses a silica-gel scar removing and repairing product containing hyaluronic acid and antibacterial peptide. The silica-gel scar removing and repairing product product is prepared from, by weight, 0.5-10 parts of antibacterial peptide, 100-200 parts of polydimethylsiloxane, 100-200 parts of polydimethylsiloxane cross-linked polymers, 10-50 parts of hyaluronic acid, 4-6 parts of carbomer, 5-8 parts of triethanolamine, 100-150 parts of glycerol and 420-600 parts of purified water. A preparation method of the silica-gel scar removing and repairing product includes the steps that 1, purified water and hyaluronic acid form a hyaluronic acid solution; 2, purified water and antibacterial peptide form an antibacterial peptide solution; 3, glycerol, purified water and triethanolamine are sequentially added into carbomer to form a carbomer solution; 4, the hyaluronic acid solution and the antibacterial peptide solution are sequentially added into the carbomer solution, stirring is conducted, polydimethylsiloxane and polydimethylsiloxane cross-linked polymers are added to form a mixture, the mixture is uniformly stirred and passes through a colloid grinder, and the finished product is obtained. The silica-gel scar removing and repairing product can cure and prevent scars, has antibacterial and anti-inflammation effects, and further has the functions of conducting protection, relieving pain and itching, powerfully preserving moisture and softening and repairing the scars.

Description

Technical field [0001] The invention relates to the technical field of skin scar repair products, in particular to a silicone gel scar removal repair product containing hyaluronic acid and antibacterial peptides and a preparation method thereof. Background technique [0002] After burns, traumas, and surgical operations, the skin and soft tissues at the wound healing site are severely damaged and cannot be repaired by themselves. Instead, fibrous tissue forms hyperplastic scars or keloids, leaving local symptoms that affect skin function and beauty. According to statistics from the Southern Institute in 2012, nearly 400 million people in China suffer from scars. Scars afflict people’s normal life, study, marriage, etc., especially when scars are formed in the bare parts, which seriously affect and hit people’s self-esteem. At present, clinical medicine is basically treated through surgical repair and drug softening. This treatment cycle Long and expensive. Therefore, research o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/32A61K38/16A61P17/02A61P31/02A61K31/80A61K31/728
CPCA61K38/16A61K9/0014A61K9/06A61K31/728A61K31/80A61K47/32A61K2300/00
Inventor 陈洪钢
Owner 国械(上海)贸易有限公司
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