Application of polymethoxylflavone in preparing medicine for treating melanoma

A technology for polymethoxyflavones and melanoma, which is applied to the application field of polymethoxyflavones in the preparation of medicines for treating melanoma, can solve problems such as unclear etiology, and achieves wide source of raw materials, improved inhibitory effect, and improved inhibition of melanoma. effect of growth
CN107007591APending Publication Date: 2017-08-04HUANGGANG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUANGGANG NORMAL UNIV
Publication Date
2017-08-04

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Abstract

The invention relates to polymethoxyflavone for treating melanoma. The effective ingredients of the polymethoxylflavone comprise one or multiple of hesperetin, nobiletin, sinensetin, 5-hydroxy-3,6,7,3',4'-pentamethoxylflavone, 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone, and 5-hydroxy-6,7,4'-trimethoxylflavone. The polymethoxylflavone has the advantages that after the polymethoxylflavone acts for 48h, the survival rates of melanoma cell lines A2058 and A375 are respectively 42% and 26%; compared with a contrast group, the inhibition action of the polymethoxylflavone on the tumor growth in a C57b1 / 6 rat inoculated with the melanoma cell lines A375 is increased by 2.75 times.
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Description

technical field

[0001] The invention relates to the application of polymethoxylated flavones in the preparation of medicines for treating melanoma. Background technique

[0002] Melanoma is a malignant tumor formed after melanocytes in the skin, mucous membrane, and choroid of the eye become cancerous. It is the most malignant tumor among skin tumors and is prone to distant metastasis. The primary sites of melanoma are mostly the soles of the feet, toes, the ends of the fingers, and under the nails. For Caucasians such as Europe and the United States, the main factor for the formation of melanoma is the formation of DNA mutations caused when the skin is exposed to ultraviolet rays. For acral melanoma in Asia and Africa, the etiology is still unclear. The therapeutic effect of melanoma is related to the stage of melanoma. The 5-year survival rates of patients with stage I, stage II, stage III and stage IV melanoma are 94%, 44%, 38%, and 4.6%, respectively. Early-stage mela...

Claims

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