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Medicinal composition for treating perimenopausal xerophthalmia

A perimenopausal and composition technology, applied in the field of medicine, can solve the problems of many side effects and unacceptable patients, achieve the effects of less side effects, promote the secretion of eyelid glands, and reduce the infiltration of inflammatory cells

Inactive Publication Date: 2017-08-11
孔守芳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients with dry eye syndrome caused by decreased androgen levels, local symptomatic treatment is mostly used at present, and androgen replacement therapy has many side effects, which is not easy for patients to accept

Method used

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  • Medicinal composition for treating perimenopausal xerophthalmia
  • Medicinal composition for treating perimenopausal xerophthalmia
  • Medicinal composition for treating perimenopausal xerophthalmia

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0016] The characterization of experimental example 1 medicine of the present invention

[0017]

[0018] 1 H-NMR (CDCl 3 ):δ0.85-1.03(m,4H),2.65-2.89(t,4H),3.56(s,2H),7.22-7.26(m,1H),7.36-7.61(m,6H),7.83-7.89 (m,1H), 8.69(s,1H).

experiment example 2

[0019] Experimental example 2 the effect of medicine treatment perimenopausal dry eye syndrome of the present invention

[0020] The preparation of medicine eye drops of the present invention: dissolve embodiment 1 medicine with distilled water, water: medicine mass ratio is 100:1, adds eye lubricant carboxymethyl cellulose, concentration control 1.5%, adds NaHCO 3 And KCl is used as a buffer system, and the concentration is controlled below 0.1%. At this time, check the physical and chemical properties of pH, osmotic pressure, specific gravity, surface tension, viscosity and refractive index, and then adjust the content of drugs, eye lubricants, and buffer systems to achieve: pH 7.3-7.8; osmotic pressure: 311- 350mOsm; specific gravity: approximately equal to 1; surface tension: 40-50dyn cm -2 ; Viscosity: slightly higher than water; Refractive index: 1.336 standard. Finally, the preservative benzalkonium bromide is added, and its concentration is controlled to 0.005% by we...

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Abstract

The invention discloses a medicinal composition for treating perimenopausal xerophthalmia. The medicinal composition has the innovative structure shown in the description. The medicine provided by the invention can obviously improve the dry eye SIT caused by decrease of the perimenopausal gonadal hormone concentrations, change the tear protein components, promote the eyelid glandular secretion, and effectively reduce the inflammatory cell infiltration of the androgen dysfunctional xerophthalmia and the basal cellular atrophy of the corneal epithelium, belongs to a medicine which is safe and effective, has the simple administration route, has small side effects, and can be used by patients for a long term in treating the dry eye disease, and therefore, the medicinal composition has the wide clinical application and promotion values.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating perimenopausal dry eye syndrome. Background technique [0002] Dry eye syndrome is an unstable tear film and ocular surface damage caused by abnormal tear quantity or quality, which seriously affects the vision and life of patients, and the prevalence rate is increasing year by year. The eye is one of the important target organs for the action of sex hormones. The level of sex hormones decreases, the tear film is unstable, and the local inflammatory response increases, leading to the formation of dry eye. For patients with dry eye syndrome caused by decreased androgen levels, local symptomatic treatment is currently used, but androgen replacement therapy has many side effects and is not easy for patients to accept. Therefore, finding an alternative drug in clinic has become an urgent problem to be solved in ophthalmology. ...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61P27/02
CPCA61K31/496
Inventor 卜风雷
Owner 孔守芳
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