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Preparation method of sugar-free four-herb Chinese medicine drug granules

A technology of traditional Chinese medicine granules and sugar-free type, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., and can solve problems such as moldy deterioration, inconvenient carrying, and large oral doses

Inactive Publication Date: 2017-08-18
贵阳市云岩区人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original prescription is administered in the form of decoction, which has a significant curative effect through clinical observation. However, because the decoction needs to be newly prepared before use, the oral dose is large, and it is prone to mold and deterioration after long-term storage. It is inconvenient to carry and does not meet the needs of modern medicine. Therefore, it is necessary Change the original dosage form to facilitate clinical medication

Method used

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  • Preparation method of sugar-free four-herb Chinese medicine drug granules
  • Preparation method of sugar-free four-herb Chinese medicine drug granules
  • Preparation method of sugar-free four-herb Chinese medicine drug granules

Examples

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Effect test

Embodiment 1

[0073] A preparation method of Eryanhuguo sugar-free granule, comprising 40g of rock cowpea, 40g of rock cabbage, 40g of knotweed, 40g of fruit upper leaves, 25.5g of dextrin, 4.5g of soluble starch, and 0.45g of aspartame.

[0074] Take by weighing the four medicinal materials of the prescription dose, add 8 times the amount of water, reflux and extract 3 times, each time for 1 hour, combine the extracted filtrate three times, concentrate to a thick paste with a relative density of 1.17, add ethanol to make the ethanol volume fraction of the medicinal solution be 70%, carry out alcohol precipitation to remove impurities, and after 24 hours, wave it in a water bath until the liquid has no alcohol smell, concentrate, and then prepare the granules of Erwohuguo thick paste (the content of lycanthin is 197.26μg / g) , mix the thick paste with dextrin, soluble starch and aspartame evenly in proportion, wet granulate, and dry to obtain the finished granule of the present invention.

Embodiment 2

[0076] A preparation method of sugar-free Eryanhuguo traditional Chinese medicine granules, characterized in that it is carried out according to the following steps:

[0077] (1) Weigh 40g of rock cowpea, 40g of rock cabbage, 40g of Polygonum cuspidatum, and 40g of the upper leaves of the fruit, and add 8 times the amount of water to decoct. Concentrate with a relative density of 1.17;

[0078] (2) Add ethanol to the concentrated solution so that the volume fraction of ethanol is 70%, carry out alcohol precipitation, alcohol precipitation at 4°C for 24 hours, wave in a water bath until the liquid has no alcohol smell, and concentrate to obtain the Eryan of the granule Huguo Thick Paste (with 203.45 μg / g of shiokiranin).

[0079] (3) Mix the thick paste with dextrin and soluble starch, add aspartame, add an appropriate amount of 80% ethanol, and wet granulate; wherein the mass ratio of thick paste to dextrin, soluble starch and aspartame is 10 :17:3:0.3;

[0080] (4) Dry the...

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Abstract

The invention discloses a preparation method of sugar-free four-herb Chinese medicine drug granules. The sugar-free four-herb Chinese medicine drug granules are prepared by weighing four medical herbs, namely, 3-10 parts of fewflower lysionotus, 3-10 parts of rhizomes or herbs of purple bergenia, 2-7 parts of giant knotweed rhizomes and 2-7 parts of herbs of denseflower bulbophyllum, eight times of water is added, the medical herbs are decocted three times, decoction lasts for 1 hour each time, after decoction is conducted three times, filtrates are combined and concentrated into a concentrated solution of which the relative density is 1.17, ethyl alcohol is added into the concentrated solution to enable the volume fraction of the ethyl alcohol to be 70%, alcohol precipitation is conducted for 24 hours, and a solution is concentrated into thick paste; after the thick paste, dextrin and soluble starch are mixed, aspartame is added, then, 80% ethyl alcohol is added to conduct wet granulation, and finished products of the sugar-free four-herb granules are obtained. Pharmacodynamics experiments are conducted on the prepared granules, the prepared granules are good in effect, and compared with traditional decoction of Chinese medicine, the prepared granules have the advantages of being convenient to transport, carry, store, take and the like. The sugar-free four-herb Chinese medicine drug granules are good in mouthfeel, can be used by patients suffering from diabetes, obesity and the like, and have very wide development prospects.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a preparation method of sugar-free cough-relieving and anti-inflammatory traditional Chinese medicine granules, more specifically, a preparation method of sugar-free Eryanhuguo traditional Chinese medicine granules. Background technique [0002] Eryan Huguo Decoction is a prescription that has been used clinically by famous old Chinese medicine practitioners in the Affiliated Hospital of Guizhou Medical University for many years. It is composed of four traditional Chinese medicines: rock cabbage, rock cowpea, knotweed, and fruit leaves. , mainly treating cough and asthma caused by wind-heat and phlegm-heat accumulation. The original prescription is administered in the form of decoction, which has a significant curative effect through clinical observation. However, because the decoction needs to be newly prepared before use, the oral dose is large, ...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/16A61K47/36A61P11/06A61P11/14
CPCA61K9/1652A61K36/185A61K36/704A61K36/898A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 饶海覃容贵徐昌艳周道堂曹旭林
Owner 贵阳市云岩区人民医院
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