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Cross-linked composite polyvinyl alcohol material

A polyvinyl alcohol and cross-linking agent technology, applied in the field of biomedicine, can solve the problems of lack of targeting of drug carriers, biocompatibility to be further improved, and difficult tissue growth.

Inactive Publication Date: 2017-08-18
SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, polyvinyl alcohol is also a good medical embolic material, which can be used as an effective means for the treatment of tumor vascular embolization, arteriovenous malformation, bleeding and other diseases, and can also be used as a long-acting anti-wrinkle cosmetic injection filling material and targeted therapy. Drug carrier, however, the currently used polyvinyl alcohol microspheres have the following disadvantages: 1. The tissue is not easy to grow into, and the compatibility with biological tissue needs to be further improved; 2. The lack of targeting as a drug carrier; 3. As a drug carrier Materials need to be prepared by adding drugs during the preparation process into drug-loaded membranes or drug-loaded microspheres, which affects the free play of doctors in clinical drug selection

Method used

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  • Cross-linked composite polyvinyl alcohol material
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  • Cross-linked composite polyvinyl alcohol material

Examples

Experimental program
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preparation example Construction

[0074] Another aspect of the present invention provides a method for preparing the crosslinked composite polyvinyl alcohol material, comprising the following steps: reacting polyvinyl alcohol and functional factors in the presence of a crosslinking agent and a catalyst to prepare the crosslinked composite material Polyethylene material. The reaction can specifically be a cross-linking reaction, more specifically an emulsification cross-linking reaction, the polyvinyl alcohol molecules and the functional factor molecules can be bonded and cross-linked to form a network structure under the action of a cross-linking agent and / or a catalyst The relative molecular weight of the polyvinyl alcohol used can generally be 20,000-300,000, or 30,000-200,000.

[0075]In the preparation method of the cross-linked composite polyvinyl alcohol material provided by the present invention, polyvinyl alcohol and functional factors are usually dispersed in an appropriate amount of water, and the wa...

Embodiment 1

[0097] Preparation of cross-linked polyvinyl alcohol microspheres

[0098] Under stirring conditions, add 40ml of liquid paraffin to a 100mL beaker, and then add 2.0g of surfactant Span-80 to form the continuous phase oil phase; after stirring for a period of time, add 20ml of PVA aqueous solution with a mass fraction of 5% to the oil phase , after mixing well, 1 g of STMP was added as a crosslinker, and finally 1 ml of NaOH was added as a catalyst. Set the rotation speed to 400r / min, the temperature to 50°C, and the reaction time to 16h.

[0099] After the cross-linking reaction is over, let it stand for 30 minutes. Add a small amount of absolute ethanol, put it in a centrifuge for centrifugation, take out the supernatant, wash the precipitate repeatedly with absolute ethanol, isopropanol and pure water, and finally put it in a blast drying oven for 24 hours to obtain a white The powder is the cross-linked polyvinyl alcohol microspheres. The particle size of the microsphere...

Embodiment 2

[0101] 1) Infrared spectrum analysis:

[0102] The PVA raw material and the cross-linked polyvinyl alcohol microspheres prepared in Example 1 were respectively mixed with potassium bromide, ground, and pressed into tablets at 3900 to 600 cm -1 Infrared scanning within range. Compare the characteristic peaks before and after the reaction, analyze the structure of the product, and determine the generation of the cross-linked product. The experimental results are as follows figure 1 , figure 2 shown.

[0103] Since PVA contains a large amount of -OH, it will undergo esterification reaction with STMP, resulting in cross-linking and generating phosphate ester products. Comparing the spectrum of PVA and PVA after cross-linking, it can be found that the PVA after cross-linking is at 3200-3500cm -1 The hydroxyl peak in the range changed, indicating that STAM reacted with the hydroxyl in PVA. at 2937cm -1 The absorption peak at is the asymmetric stretching vibration peak of the ...

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Abstract

The invention relates to implant and intervention materials and drug carrier materials in the biological medicine field, in particular to a cross-linked composite polyvinyl alcohol material. The cross-linked composite polyvinyl alcohol material is prepared from, by weight, 75-99.5 parts of cross-linked polyvinyl alcohol and 0.5-25 parts of functional factors. The cross-linked composite polyvinyl alcohol material is not prone to aggregation and is good in safety and biocompatibility.

Description

technical field [0001] The invention relates to an implant intervention material and a drug carrier material in the field of biomedicine, in particular to a cross-linked composite polyvinyl alcohol material. Background technique [0002] In 1955, Vanderhoff and others successfully synthesized monodisperse polystyrene microspheres, which opened up a new research field of polymer science. Polymer microspheres not only have the advantages of easy separation and extraction unique to solid phase carriers, but also have the characteristics of low cost, large specific surface area, good monodispersity, easy preparation and functionalization. At present, polymer microspheres have been widely used in materials science, chemical engineering, information science and other fields. [0003] Polyvinyl alcohol is a water-soluble polymer obtained by alcoholysis of polyvinyl acetate. It is a water-soluble polymer material. Due to its good film-forming properties, tensile strength and wear r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/24C08L29/04C08L89/00C08L5/10C08L1/28C08L5/08C08L3/08C08L5/02A61L31/04A61L31/14A61K47/32
CPCC08J3/24A61K47/32A61L31/048A61L31/14C08J3/246C08J2329/04C08J2401/28C08J2403/08C08J2405/02C08J2405/08C08J2405/10C08J2489/00C08L29/04C08L2205/02C08L2205/03C08L89/00C08L5/10C08L5/08C08L5/02C08L1/28C08L3/08
Inventor 廖囡囡吴昌琳刘光万
Owner SUZHOU BOCHUANG TONGKANG PHARM TECH CO LTD
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