Method for extracting levodopa from conversion solution

Abstract

The invention relates to a method for extracting levodopa from a conversion solution. The method comprises the steps of adding inorganic acid into the conversion solution in a flow manner, then, carrying out adsorption with absorbent resin, carrying out eluting, and the like. According to the method, the existing process of firstly carrying out levodopa extraction and then treating pyrocatechin-containing wastewater is abandoned, an extraction process for recovering pyrocatechin while carrying out levodopa extraction is invented, subsequent wastewater treating pressure is alleviated, and unexpended pyrocatechin is recovered while the levodopa is purified, so that subsequent wastewater treatment becomes simple, the extraction cost is greatly reduced, and the subsequent sewage treatment cost is reduced.

Description

technical field [0001] The invention belongs to the field of post-fermentation extraction, and in particular relates to a method for extracting levodopa from transformation liquid. Background technique [0002] Levodopa, also known as 3,4-dihydroxyphenylalanine, is a white crystalline powder, odorless and tasteless, insoluble in ethanol, chloroform and acetone, soluble in dilute acid, as an important biologically active substance , Levodopa is the precursor of the neurotransmitter dopamine, which can pass through the blood-brain barrier, enter the cerebral circulation, and reach the central nervous system. Treat Parkinson's disease. [0003] Levodopa is the first choice and the most effective drug for the treatment of senile Parkinson's disease. In addition, Levodopa also has the effect of treating amblyopia and heart failure. Although there will be some side effects after long-term use, more than 40 years old Years have passed, and there are still no better alternatives. ...

AI Technical Summary

Problems solved by technology

[0005] Microbial enzyme conversion method is a kind of mild reaction conditions, environmentally friendly preparation method of levodopa, however, at present, there are few reports on the industrialization of levodopa preparation by microbial enzyme method, mainly because the conversion liquid purification method produces Wastewater is more difficult to treat

Chinese patents CN 106117071A and CN106117072A have announced two methods for purifying levodopa in the conversion liquid, but these two methods do not provide a treatment method for purifying waste water, and the mother liquor waste water or centrifugal waste water of these two extraction processes all contain Catechol, the cost of follow-up treatment is higher

Phenol-containing wastewater is harmful to health and causes serious environmental pollution. At the same time, levodopa in wastewater cannot be recovered

Therefore, the high concentration of catechol in the current wastewater limits the industrialization of levodopa microbial enzymatic conversion method