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Use of nicotinamide adenine dinucleotide in preparation of drug for treating cancer pain

A technology of nicotinamide adenine and dinucleotide, which is applied in the direction of drug combination, non-central analgesics, antipyretics, etc., and can solve the problems of gastrointestinal reactions such as addiction

Inactive Publication Date: 2017-09-15
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current traditional cancer pain treatment drugs include non-steroidal anti-inflammatory drugs and opioids, but long-term use can cause severe gastrointestinal reactions and addiction

Method used

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  • Use of nicotinamide adenine dinucleotide in preparation of drug for treating cancer pain
  • Use of nicotinamide adenine dinucleotide in preparation of drug for treating cancer pain
  • Use of nicotinamide adenine dinucleotide in preparation of drug for treating cancer pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Nicotinamide adenine dinucleotide has an analgesic effect on cancer pain, which will be further explained through pharmacodynamic experiments below.

[0019] The experimental animals were 20g ICR mice, which were purchased from the Experimental Animal Center of Tongji University. Feeding conditions: standard feed, room temperature maintained at (24±2)°C, humidity 50-60%, daily light and dark time 12h each, before the experiment, The animals were placed in the experimental environment for 3 days to acclimatize.

[0020] Take 18 ICR mice (female, about 20g), and divide them into three groups randomly, 6 in each group, respectively normal saline group (intrathecal injection, 10ul), nicotinamide adenine dinucleotide group (two concentrations respectively 50ug (8mmol / L), 500ug (80mmol / L), intrathecal injection, 10ul), respectively, on the 20th day after inoculating 4T1 mouse breast cancer cells into the bone marrow cavity of mice (that is, cancer pain modeling is successful,...

Embodiment 2

[0022] Nicotinamide adenine dinucleotide has an analgesic effect on cancer pain, which will be further explained through pharmacodynamic experiments below.

[0023] Take 30 ICR mice (male, about 20g) and randomly divide them into five groups. On the 20th day, the cancer pain mice were given intrathecal saline (10ul) and nicotinamide adenine dinucleotide intrathecally at a concentration of 80mmol. / L, the injection volume is 0.1ul / g and 1ul / g respectively. The conventional Von Frey fiber filaments are used for measurement by the up and down method, and the mechanical threshold values ​​of 15min, 30min, 45min, 1h, 2h, 3h, and 6h after administration are determined respectively. Compared with the normal saline group, the nicotinamide adenine dinucleotide group inhibited the mechanical pain threshold of cancer pain at 15min-3h, indicating that nicotinamide adenine dinucleotide has an anti-cancer pain effect.

Embodiment 3

[0025] Nicotinamide adenine dinucleotide has an analgesic effect on cancer pain, which will be further explained through pharmacodynamic experiments below.

[0026] Take 30 ICR mice (male, about 20g) and randomly divide them into five groups. On the 20th day of cancer pain mice, give normal saline (10ul) and nicotinamide adenine dinucleotide to the muscle tissue around the bone tumor, the concentrations are respectively 8mmol / L and 80mmol / L, the injection volume is 1u l / g and 10ul / g respectively. The conventional Von Frey fiber filaments are used for measurement by the up and down method, and the mechanical threshold values ​​of 15min, 30min, 45min, 1h, 2h, 3h, and 6h after administration are determined respectively. Compared with the normal saline group, the nicotinamide adenine dinucleotide group inhibited the mechanical pain threshold of cancer pain at 15min-3h, indicating that nicotinamide adenine dinucleotide has an anti-cancer pain effect.

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Abstract

The invention relates to a use of nicotinamide adenine dinucleotide in preparation of a drug for treating cancer pain. A modern pharmacological experiment proves that after the interior of an ICR mouse marrow cavity is inoculated with 4T1 mouse breast cancer cells, the nicotinamide adenine dinucleotide improves a mouse paw withdrawal threshold and has a pain alleviating effect and thus the nicotinamide adenine dinucleotide can be used for treating cancer pain.

Description

technical field [0001] The invention belongs to the application of nicotinamide adenine dinucleotide, in particular to the application of nicotinamide adenine dinucleotide in preparing medicine for treating cancer pain. Background technique [0002] Pain is the most common symptom of cancer patients, about 30-50% of cancer patients will have moderate to severe pain, especially in advanced cancer patients, about 75-95% will have uncontrollable chronic pain, of which 45% of cancer patients The severe pain cannot be relieved, and bone cancer pain is the most common refractory type among them, which seriously affects the quality of life of patients. Although WHO has regarded the treatment of cancer pain as an important social problem, there is still a lack of effective treatment methods. The current traditional cancer pain treatment drugs include non-steroidal anti-inflammatory drugs and opioids, but long-term use can cause severe gastrointestinal reactions and addiction. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7084A61P29/00A61P35/00
CPCA61K31/7084
Inventor 张玲
Owner TONGJI UNIV
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