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Ophthalmic gel for konjac glucomannan and preparation method thereof

A technology of konjac glucomannan and glucomannan eye, applied in the field of ophthalmic gel and its preparation, to achieve the effects of reducing the number of medications, good water solubility and high bioavailability

Inactive Publication Date: 2017-09-22
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is suitable for symptoms such as myopia, dry eyes, photophobia, wind and tears, blurred vision, etc. It can also be used for daily health care of conjunctivitis, trachoma, and blepharitis. Apply externally, wash at a fixed time, and cannot cause sustained release of the drug for a long time

Method used

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  • Ophthalmic gel for konjac glucomannan and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1, a kind of preparation method of konjac glucomannan ophthalmic gel, comprises the following steps:

[0023] (1) Preparation of purified konjac glucomannan powder: In parts by mass, add 4 parts of konjac fine powder to 2000 parts of deionized water at 60°C at room temperature at 350 r / min while stirring, stir for 20 minutes, let stand for 2 hours, and pump Filter and retain the filtrate, and concentrate its volume to 15%; use ethanol with a volume ratio of 85% as a precipitant, pour it into the concentrated filtrate, stir while pouring, and then dry the precipitate in a drying oven at 50°C for 2 hours , and then dried in a vacuum oven at 20°C until the quality was constant to obtain purified konjac glucomannan powder;

[0024] (2) Preparation of matrix: Take 2 parts of glycerol and 0.4 part of hypromellose, add 45 parts of deionized water at room temperature, after the glycerol and hypromellose are completely dissolved, put them in a water bath at 30 °C, and...

Embodiment 2

[0027] Embodiment 2, a kind of preparation method of konjac glucomannan ophthalmic gel, comprises the following steps:

[0028] (1) Preparation of purified konjac glucomannan powder: According to mass parts, add 8 parts of konjac fine powder to 3000 parts of deionized water at 70 °C at room temperature at 350 r / min, stir for 25 min, and let stand for 2 h. Suction filtration to retain the filtrate, and concentrate its volume to 25%; use ethanol with a volume ratio of 85% as a precipitant, pour it into the concentrated filtrate, stir while pouring, and then dry the precipitate in a drying oven at 50°C 2.5 h, and then dried in a vacuum oven at 25°C until the quality was constant to obtain purified konjac glucomannan powder;

[0029] (2) Preparation of matrix: Take 4 parts of glycerol and 0.5 part of hypromellose, add 50 parts of deionized water at room temperature, after the glycerol and hypromellose are completely dissolved, put them in a water bath at 40 °C, and Add 5 parts of...

Embodiment 3

[0032] Embodiment 3, a kind of preparation method of konjac glucomannan ophthalmic gel, comprises the following steps:

[0033](1) Preparation of purified konjac glucomannan powder: In parts by mass, add 12 parts of konjac fine powder to 4000 parts of deionized water at 80°C at room temperature at 350 r / min, stir for 30 min, and let stand for 2 hours. Suction filtration to retain the filtrate, and concentrate its volume to 30%; use ethanol with a volume ratio of 85% as a precipitant, pour it into the concentrated filtrate, stir while pouring, and then dry the precipitate in a drying oven at 50°C 3 h, then dried in a vacuum oven at 30°C until the quality was constant, and purified konjac glucomannan powder was obtained;

[0034] (2) Preparation of matrix: Take 6 parts of glycerol and 0.6 parts of hypromellose, add 55 parts of deionized water at room temperature, after the glycerol and hypromellose are completely dissolved, put them in a water bath at 50 °C, and Add 6 parts of ...

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Abstract

The invention relates to an ophthalmic gel for konjac glucomannan and a preparation method thereof. The preparation method of the ophthalmic gel for konjac glucomannan comprises preparing konjac glucomannan purified powder, preparing a substrate, preparing a medicine liquor and preparing the gel. The konjac glucomannan is used as a main material and serves as a carrier, the gel property, water-retaining property, water-solubility and antibacterial property of the gel are utilized, sulfacetamide sodium is assisted, and due to dihydrofolate synthetase for para aminobenzoic acid competition bacteria, the folate metabolism of bacteria is blocked, required purine and nucleic acid cannot be obtained, and the growth and propagation of the bacteria are restricted. The konjac glucomannan is stable in drug carrying ability, and the prepared ophthalmic gel for konjac glucomannan is high in bioavailability, high in mold resistance and good in water solubility. The ophthalmic gel for konjac glucomannan has the advantages of simple materials, convenient material taking, low cost, easy preparation, good water solubility, good biodegradable and bioavailability, nontoxicity, innocuity and the like, and the novel efficient ophthalmic gel new product is increased for the field of medical treatment and health.

Description

technical field [0001] The invention relates to an eye gel and a preparation method thereof, in particular to a konjac glucomannan eye gel and a preparation method thereof. Background technique [0002] Common infectious eye diseases and bacterial eye diseases are mainly treated with antibiotic ophthalmic drugs, which are prone to drug resistance. With the extensive use of antibiotics, drug-resistant strains have increased. Antibiotic eye medicines cannot be used for a long time because of their side effects. Therefore, the development of new ophthalmic drugs for the treatment of eye diseases has become a research hotspot. [0003] Gel refers to latex liquid or semi-solid preparations made of drugs and suitable auxiliary materials. The gel is water-soluble or oil-soluble. After local administration, the surface skin of the affected area absorbs well and has low side effects. At the same time, the gel is easy to use and suitable for various types of patients, and its accep...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/36A61K31/63A61P27/02A61P31/04
CPCA61K9/06A61K9/0048A61K31/63A61K47/36
Inventor 庞杰王林吴佳煜穆若郡王维海倪永升刘子奇龚静妮洪馨
Owner FUJIAN AGRI & FORESTRY UNIV
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