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Modified cells evoking reduced immunogenic responses

An immunogenic, cellular technology, applied in the field of cell therapy, which can solve the main obstacles that have not been overcome, etc.

Active Publication Date: 2017-09-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for the clinical application of stem cell-based cell replacement therapy, major hurdles remain unsurmounted (e.g. allograft immune rejection)

Method used

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  • Modified cells evoking reduced immunogenic responses
  • Modified cells evoking reduced immunogenic responses
  • Modified cells evoking reduced immunogenic responses

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Embodiment Construction

[0034] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present disclosure, the preferred methods and materials are described. For the purposes of this disclosure, the following terms are defined below.

[0035] The articles "a" and "an" are used herein to refer to one or to more than one (ie, to refer to at least one) of the grammatical object of the article. By way of example, "an element" means one element or more than one element.

[0036] "About" means an amount, level, value, quantity, frequency, percentage, dimension, size, amount compared to a reference amount, level, value, amount, frequency, percentage, dimension, size, amount, weight, or length , a change in weight or length of up to 30, 25, 20, 15, 1...

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Abstract

Provided are composition, methods and systems associated with a genetically modified stem cell. The modified stem cell includes a reduced amount of Major Histcompatibility Complex II (MHC II) as compared to a corresponding wild-type cell. Further, the modified cell has decreased immunogenicity as compared to the corresponding wild-type cell.

Description

[0001] Cross references to related patent applications [0002] This application claims priority to US Provisional Patent Application No. 62 / 104,709, entitled "Cells Modified to Elicit a Reduced Immunogenic Response," filed January 17, 2015, which is hereby incorporated by reference in its entirety. technical field [0003] The present disclosure relates to cell therapy. More specifically, the present disclosure relates to modified cells that elicit a reduced immunogenic response. Background technique [0004] Stem cells have the ability to self-renew and differentiate. Under certain conditions, stem cells can differentiate into a variety of functional cells. According to the stage of development, stem cells can be divided into two types: embryonic stem cells (ES cells) and adult stem cells: according to the potential of development, stem cells can be divided into three types: totipotent stem cells (TSC), pluripotent stem cells and unipotent stem cells. Stem cells are un...

Claims

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Application Information

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IPC IPC(8): C12N5/0735C12N5/074C12N5/0775C12N5/0789C12N5/0797C12N5/095C07K14/74A61K48/00
CPCC12N5/0603C12N5/0639C12N2510/00A61K2239/31A61K2239/38A61K39/461A61K39/4644A61K35/545C12N5/0606
Inventor 肖磊陈海德崔春李阳崔迪
Owner ZHEJIANG UNIV