Use of glycerol kinase as a therapeutic target for disorders of glucose metabolism

A technology of glycerol kinase and uses, which is applied in the field of glycerol kinase as a therapeutic target for disorders of glucose metabolism, and can solve problems such as no report on the effect of glycerol kinase
CN107308450BActive Publication Date: 2020-08-04SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
Publication Date
2020-08-04

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Abstract

The present invention relates to uses of glycerokinase as a glucose metabolism disorder treatment target. According to the present invention, the results show that glycerokinase can catalyze glycerol to generate 3-phosphoglycerol so as to participate in gluconeogenesis, can regulate the expressions of gluconeogenesis enzyme glucose-6-phosphatase (G6pase) and phosphoenolpyruvate carboxykinase (PEPCK) through an AKT-FOXO1 signaling pathway so as to regulate gluconeogenesis, and can provide important effects in the maintaining of the blood glucose homeostasis, such that the glycerokinase and the regulator thereof are the new target for blood glucose regulation and diabetes treatment.
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Description

technical field

[0001] The invention belongs to the field of biopharmaceuticals, and more specifically, the invention relates to the use of glycerol kinase as a therapeutic target for disorders of glucose metabolism. Background technique

[0002] Hepatic glucose metabolism (including blood glucose absorption, glycogen synthesis and breakdown, gluconeogenesis and output) plays an important role in maintaining blood glucose homeostasis. Hepatic gluconeogenesis hyperactivity is an important pathological mechanism of type 2 diabetes mellitus. Increased hepatic glucose output leads to elevated blood sugar. Correcting hyperglucose production is beneficial to control the pathogenesis of diabetes and secondary diseases. Therefore, research on inhibitors targeting glycogen production is of great significance for the control and treatment of diseases related to glucose metabolism disorders, including metabolic syndrome and type 2 diabetes.

[0003] Glycerol kinase can catalyze the ph...

Claims

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