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Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract

A tomato extract, technology of extract, applied in the field of preparation of tomato extract and use of tomato extract as antihypertensive agent to regulate blood pressure

Pending Publication Date: 2017-11-28
PROVEXIS NATURAL PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

ACE is not specific for the transition of angiotensin I to angiotensin II

Method used

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  • Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract
  • Use of tomato extract as antihypertensive agent and process for making water soluble sugar free tomato extract

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Experimental program
Comparison scheme
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Embodiment approach

[0037] While this disclosure refers to some illustrative embodiments, it should be understood that these embodiments have been presented by way of example and not limitation.

[0038] tomato extract

[0039] Provided herein is a tomato extract having beneficial activity on cardiovascular health. For example, data collected during the development of certain embodiments of the technology show that the extract reduces ACE activity in normal serum in a dose-dependent manner. Furthermore, the collected data also indicated that the active ingredients in the tomato extract are water-soluble and have a very different structure from the fat-soluble compounds. The extract may be fractionated, for example by molecular weight filtration or chromatography on a suitable support, to isolate one or more active fractions therein. In some embodiments, fractionation, eg, using a Lipidex-1000 column, results in the removal of lipids. In some embodiments, the extract is fractionated by solid ph...

Embodiment

[0072] Preparation of tomato extract

[0073] During the development of embodiments of the technology described herein, tomato extracts were prepared and tested. In some embodiments, the tomatoes are homogenized with a Brown Turbo Mixer on top speed for 20-30 seconds. The homogenate was then centrifuged at 9000 xg for 15 minutes at 4°C. The supernatant was then boiled for 30 minutes and centrifuged again. The supernatant was removed and lyophilized overnight. The dried material was dissolved in double distilled water and the pH was adjusted to 7.4. Samples were ultrafiltered using a Microsep(TM) centrifugal device (Pall Corporation, USA) with a molecular weight cut-off of 1000 kDa. The ultrafiltrate was collected, lyophilized and reconstituted in water; the pH was adjusted to 7.4 for further studies.

[0074] Removal of water-soluble sugars in extracts

[0075] In some embodiments of the tomato extract composition, the tomato extract comprises more than 50% inactive wate...

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Abstract

The invention provides a tomato extraction technology. Specifically, the invention provides a technology of preparing tomato extract and taking tomato extract as a medicament for treating hypertension and regulating blood pressure. Disclosed herein is a use of a composition comprising a tomato extract in the preparation of a medicament for treating hypertension, or for treating a condition or disorder selected from the group consisting of stroke, aneurysm, coronary heart disease (CHD), heart attack, atherosclerosis, ischemic heart disease, left ventricular hypertrophy, encephalopathy, congestive heart failure, hypertensive retinopathy, gout, tachycardia, kidney dysfunction diabetes, and diseases related with ACE activity and / or hypertension.

Description

[0001] This application is a Chinese patent application 201380031408.9 with an application date of April 22, 2013, the applicant is the University of Oslo, and the title of the invention is "Use of Tomato Extract as an Antihypertensive Agent and Method for Manufacturing Water-Soluble Sugar-Free Tomato Extract" divisional application. technical field [0002] This article provides techniques relating to tomato extracts, particularly, but not exclusively, techniques relating to the preparation and use of tomato extracts as antihypertensive agents to regulate blood pressure. Background technique [0003] Cardiovascular disease is a major cause of morbidity and mortality, so primary and secondary prevention of cardiovascular disease is a public health priority. Hypertension, hyperlipidemia, and thrombocytosis are recognized risk factors for cardiovascular disease. Among them, hypertension is recognized as a major chronic disease. Hypertension was defined as systolic blood pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P9/12A61P9/10A61P35/00A61P9/00A61P25/00A61P9/04A61P19/06A61P9/06A61P13/12A61P3/10
CPCA23L33/105A61K9/2018A61K9/4858A61K9/4866A61K9/4875A61K36/81A23V2002/00A61K2236/31A61K2236/00A61K2236/53A61K2236/55A23V2200/326A23V2250/21A61P13/12A61P19/06A61P25/00A61P27/02A61P35/00A61P43/00A61P9/00A61P9/04A61P9/06A61P9/10A61P9/12A61P3/10
Inventor A·K·杜塔罗伊
Owner PROVEXIS NATURAL PROD
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