Application of fully carboxylated osteocalcin in the preparation of rapid antidepressants

Abstract

An application of fully carboxylated osteocalcin in preparing a fast-acting antidepressant. The fully carboxylated osteocalcin is administered at a concentration of 80 ng / g.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a novel fast-acting antidepressant. Background technique [0002] Medication is currently the mainstay of depression treatment. Most of the currently used antidepressants are designed based on the monoamine hypothesis of depression, and exert antidepressant effects by increasing the concentration of monoamine neurotransmitters in the synaptic cleft of the central nervous system and enhancing the function of monoamine neurons. Since the 1950s, the research and development of antidepressants has made great progress, and the new generation of antidepressants has greatly improved in terms of side effects, etc., but its clinical efficacy has not achieved substantial breakthroughs, and there are still many problems. limitations. The main manifestations are as follows: ①The clinical effect is slow and there is a delayed effect. Generally, it takes 2-3 weeks to take antidepressants before the c...

AI Technical Summary

Problems solved by technology

The main manifestations are: ①The clinical effect is slow and there is a delayed effect. Generally, the clinical effect can be achieved after taking antidepressants for 2-3 weeks

②The treatment response rate is low, and only 1 / 3 of the depressed patients are effective for the first antidepressant treatment

③The phenomenon of drug resistance is obvious, and treatment-resistant depression has become a major problem in the treatment of depression

These limitations lead to extremely low compliance of patients with depression during the treatment process, making it difficult for patients to recover their physical and social functions, and bringing heavy economic burdens to families and society.

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