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A kit for predicting recurrence of breast cancer

A breast cancer and breast cancer extraction technology, applied in the biological field, can solve the problems of predicting the recurrence of breast cancer after surgery, and achieve the effect of improving the overall survival rate and having broad prospects for clinical application.

Active Publication Date: 2019-07-26
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also such cells in breast cancer tissue, namely breast cancer stem cells (BCSC). Studies have shown that the recurrence of breast cancer is closely related to the stem cells in breast cancer tissue, but there is no prediction of breast cancer based on a variety of cancer stem cells. Literature Report on Postoperative Recurrence of Carcinoma

Method used

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  • A kit for predicting recurrence of breast cancer
  • A kit for predicting recurrence of breast cancer
  • A kit for predicting recurrence of breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 The construction of the model of the present invention

[0034] 1. Experimental materials

[0035] Breast cancer patient data set: The data set and corresponding clinical information of breast cancer patients were collected from West China Hospital, and 856 cases of BIDC (Breast Invasive Ductal Carcinoma) diagnosed between 2006 and 2011 were included

[0036] patient. After screening patients with positive lymph node metastasis and no chemotherapy, a total of 407 patients with early-stage BIDC were defined as the entire dataset. This study was approved by the Ethics Committee of West China Hospital (approval number: 2013-191). All the pathological cases used were routine follow-up cases, and the patients were followed up by telephone every six months to record the patient's disease recurrence, progression and survival.

[0037] Two, construct the present invention model

[0038] 1. Detection and quantification of breast cancer stem cells (BCSC) in breas...

Embodiment 2

[0070] Embodiment 2 Verification of the model of the present invention

[0071] 1. Evaluation of breast cancer recurrence model in multiple analysis

[0072] In univariate survival analyses, age and tumor size were considered to be statistically significant clinical factors. To further investigate whether the predictive power of the prognostic group was independent of other clinical variables, we used univariate Cox proportional hazards regression analysis. We performed a 10-fold cross-validation analysis. Only 4 out of 10 cross-validation tests showed that age could not be included as an independent predictor of recurrence for statistical significance, while tumor size proved to be significant in 8 out of 10 independent recurrence predictor analyses. .

[0073] We then incorporated tumor size and RRS into a multivariate cox regression model, and in a 10-fold cross-validation test, RRS provided significant predictive power independent of tumor size. The results show that t...

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Abstract

The invention provides a kit for predicting breast cancer relapse. The kit comprises a reagent for detecting four cancer stem cells, including ALDH1A3, CD44+ / CD24-, CD49f+ and PROCR. The invention also provides an application of the kit and a construction method for a mathematical model for predicting breast cancer relapse. The kit provided by the invention can be used for judging the postoperative relapse risk of the breast cancer patient; a theoretical basis is supplied for performing clinical personalized treatment, predicting postoperative curative effect and increasing the total survivalrate of breast cancer; the clinical application prospect is wide.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a kit for predicting recurrence of breast cancer. Background technique [0002] Breast cancer is a type of malignant tumor with the highest incidence rate among female tumors. It has become a major threat to women's health. At present, surgical resection is the first choice for breast cancer patients. The main reason for poor efficacy and high fatality rate. For example, early breast invasive ductal carcinoma (BIDC) is very prone to in situ recurrence and distant recurrence after primary surgery. For breast cancer patients, especially early breast cancer patients, after surgical treatment, accurately predicting the probability of recurrence and adopting a personalized treatment plan is a major bottleneck for prolonging the survival of breast cancer patients and improving long-term curative effect. The key to overcoming breast cancer. [0003] Compared with the five-yea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/574G16B5/00
Inventor 叶丰郑鸿步宏
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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