Molecular markers, internal reference genes and application thereof, detection kit and method for constructing detection model

A technology of molecular markers and internal reference genes, which is applied in biochemical equipment and methods, microbiological determination/inspection, DNA/RNA fragments, etc., can solve problems such as expensive, genes and their detection models that have yet to be verified, and achieve reduction Effects of over-treatment and inappropriate treatment, satisfying individualized precise treatment, and perfecting technical methods
CN107574243AActive Publication Date: 2018-01-12CAPITALBIO CORP +1
8 Cites 12 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CAPITALBIO CORP
Publication Date
2018-01-12

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention especially relates to molecular markers, internal reference genes and application thereof, a detection kit and a method for constructing a detection model, belonging to the field of biotechnology. With follow-up information used for comparison, the kit provided by the invention has accuracy of 70% in predication of the risk of recurrence or death of first-visit patients with ER-positive and PR-positive breast cancers in 3-10 years after operations, wherein the prediction accuracies of a low-risk group and a high-risk group are 81.1% and 54.4%, respectively while the prediction accuracies of corresponding FFPE pathological examination results are 71.9 to 56.8%, respectively. The risk prediction model matching with the kit only needs the Ct values of the molecular markers, theage of a patient, the stage of pT and the number of LN and does not depend on other clinical pathological information, so the risk prediction model has better performance in evaluation of prognosis ofbreast cancers than simple pathological prediction results, can reduce malpractice caused by errors in pathological prediction and further improves a technical method for evaluation of prognosis of breast cancers.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a molecular marker, an internal reference gene and its application, a detection kit and a method for constructing a detection model. Background technique

[0002] Breast cancer is one of the main reasons that threaten the life and health of women all over the world. In 2013, the American Cancer Society released national cancer statistics showing that the incidence of breast cancer ranks first among female cancers, and its mortality rate ranks second. According to the latest data from the National Cancer Center, there were 232,340 new breast cancer cases and 39,620 deaths among American women in 2013. In the United States, one in eight women develops breast cancer. Although China is a country with a low incidence of breast cancer, its incidence and mortality have increased significantly in recent years. Of the 1.3 million newly diagnosed breast cancer patients worldwide each year, a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More