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Turmeric extract, preparation method and use thereof, and health care product

A technology of turmeric extract and turmeric, applied in the field of medicine, can solve problems such as liver function damage, liver lobule damage, structural changes, etc., and achieve the increase and inhibition of lipid content in hepatocytes, the inhibition of proliferation, and the increase of triglyceride content. high suppression effect

Inactive Publication Date: 2018-01-19
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the contrary, if you suffer from high blood lipids for a long time, it will also lead to fatty liver, hepatic atherosclerosis will be damaged, and the liver lobules will also be damaged, which will lead to structural changes and damage to liver function.

Method used

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  • Turmeric extract, preparation method and use thereof, and health care product
  • Turmeric extract, preparation method and use thereof, and health care product
  • Turmeric extract, preparation method and use thereof, and health care product

Examples

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preparation example Construction

[0037] The method for preparing turmeric extract according to the embodiment of the present invention is not only simple in process, but also has a higher extraction rate of turmeric extract, and the obtained turmeric extract has a significant inhibitory effect on the proliferation of liver cancer cells, and paracetamol (APAP) The induced hepatocyte injury with glutathione (GSH) depletion as the main mechanism has a good protective effect, and it has a significant effect on the increase of lipid content in hepatocytes and the increase of triglyceride content caused by oleic acid inhibitory effect.

[0038] In yet another aspect of the present invention, the present invention provides a turmeric extract. According to an embodiment of the present invention, the turmeric extract is prepared by the method described above. Therefore, the turmeric extract has a significant inhibitory effect on the proliferation of liver cancer cells, and has a good protective effect on hepatocellul...

Embodiment 1

[0045] Embodiment 1, the anti-tumor proliferation effect of turmeric extract

[0046] (1) Preparation of Turmeric Extract 1

[0047] Weigh 2.8kg of dry turmeric medicinal material, and obtain 40 mesh turmeric powder after pulverization, under the conditions of extraction pressure of 28Mpa, extraction temperature of 40°C, extraction flow rate of 30Hz, extraction time of 180min under the condition of supercritical CO 2 Extract, prepare the turmeric powder 2.21kg after deoiling.

[0048] The turmeric powder after the above-mentioned deoiling is subjected to supercritical CO under the conditions of pressure 30Mpa, temperature 40°C, ethanol concentration 95%, W raw material: W ethanol = 1:1, and the flow rate is 30Hz. 2 Extracting, extracting for 90 minutes, prepared 0.2 kg of turmeric extract 1.

[0049] (2) Culture of human liver cancer cells

[0050] Human liver cancer (HepG-2) cells, which retain the characteristics of normal human liver cells, are often used as normal liver...

Embodiment 2

[0058] Embodiment 2, the hepatoprotective effect of turmeric extract

[0059] (1) Preparation of Turmeric Extract 2

[0060] Weigh 2.5kg of dry turmeric medicinal material, after crushing, obtain 80-mesh turmeric powder, under the conditions of extraction pressure of 50Mpa, extraction temperature of 70°C, extraction flow rate of 50Hz, and extraction time of 200min, carry out supercritical CO 2 Extract and prepare turmeric powder 2.01kg after deoiling.

[0061] The turmeric powder after the above-mentioned deoiling is subjected to supercritical CO under the conditions of pressure 30Mpa, temperature 60°C, ethanol concentration 95%, W raw material: W ethanol = 1:5, and the flow rate is 30Hz. 2 Extraction, extracting for 120min, prepared 0.3kg of turmeric extract 2.

[0062] (2) Protective effect of samples on APAP-induced liver cell injury in vitro

[0063] The MTT method is used. HepG-2 cells were inoculated in a 96-well cell culture plate, and after culturing for 24 hours, ...

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Abstract

The invention discloses a turmeric extract, a preparation method and use thereof, and a health care product, and the preparation method is as follows: (1) crushing turmeric to obtain turmeric powder;(2) performing supercritical CO2 extraction on the turmeric powder to obtain deoiled turmeric powder; (3) mixing the deoiled turmeric powder with an entrainer for supercritical CO2 extraction to obtain turmeric extract. The method has the advantages of simple process and high turmeric extract extraction rate, the turmeric extract has an obvious inhibitory effect on the proliferation of hepatoma carcinoma cells, has a good protective effect on acetaminophen (APAP) induced liver cell damage with glutathione (GSH) depletion a main mechanism, and has a significant inhibitory effect on oleic acid-induced lipid content increase and triglyceride content increase in hepatic cells.

Description

technical field [0001] The invention belongs to the field of medicine, in particular, the invention relates to a turmeric extract, its preparation method, application and health care product. Background technique [0002] Insidious onset, rapid progression, and easy metastasis of liver cancer are the main reasons for the high mortality rate of liver cancer patients. Drug therapy is an important means to relieve symptoms and improve patient survival. At present, the fact that drugs for the treatment of liver cancer are far from meeting the clinical needs implies the huge potential value of this market. At present, the clinical first-line anti-hepatic cancer drugs include doxorubicin, carboplatin, cisplatin, and sorafenib. However, the clinical effective rate of these anti-liver cancer drugs is only 10-20%. It can be seen that the development of more efficient anti-liver cancer drugs has huge market potential. [0003] In addition, with the improvement of people's living s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61P1/16A61P3/06A23L33/105
Inventor 张虹唐亚林刘岩沈刚
Owner INST OF CHEM CHINESE ACAD OF SCI
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