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Maquindox nanoemulsion and preparation method thereof

The technology of acemequine and acemequine, which is applied in the field of nanoemulsion preparation, can solve the problems of difficult administration to piglets, single dosage form, low bioavailability and the like, and achieves the effects of good antibacterial effect, stable quality and controllable quality.

Inactive Publication Date: 2018-02-09
CHENGDU LINGXI SHANGPIN TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Methoquine has a good effect on yellow and white scour of piglets caused by Escherichia coli, but its dosage form is relatively single, its bioavailability is low, and it is difficult to administer to piglets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The acetylmequina nanoemulsion of this embodiment, by mass fraction: w (RH-40) = 30.25%, w (cinnamaldehyde) = 6.20%, w (acetylmequine) = 1.24%, w (distilled water) = 62.31%.

[0025] Its preparation method comprises the following steps:

[0026] (1) Add RH-40 and acetylmethaquine to a four-necked flask, and stir to mix them evenly;

[0027] (2) Fix the four-necked flask under the condition of water bath, keep the water temperature at 40~60℃, after the raw materials are fully melted, start the stirrer, and the stirring speed is 150~200rpm;

[0028] (3) After the temperature of the raw materials in the four-necked flask reaches 40~60°C, stop stirring, add cinnamaldehyde, and continue stirring for 30 minutes;

[0029] (4) Stop stirring, add hot distilled water at 40~60°C dropwise with a rubber dropper, after 3~8h of dropping, keep warm at 40~60°C for 1h;

[0030] (5) Turn off the water bath heating, cool down to room temperature, add fungicide, and continue stirring for...

Embodiment 2

[0035] In order to better realize the preparation of nanoemulsions in this example, it is further limited that the stirrers used in the preparation process are all magnetic stirrers. Other parts of this embodiment are the same as those of the foregoing embodiment, and will not be repeated here.

Embodiment 3

[0037] In order to better realize the preparation of nanoemulsions in this embodiment, it is further limited that in the step (4), the distilled water is dripped with a glue-tipped dropper. Other parts of this embodiment are the same as those of the foregoing embodiment, and will not be repeated here.

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Abstract

The invention discloses a maquindox nanoemulsion which is mainly composed of, by weight parts, 20-40 parts of RH-40, 5-15 parts of cinnamaldehyde, 0.5-2 parts of maquindox and a sufficient quantity ofdistilled water. A method for preparing the maquindox nanoemulsion includes a step 1) of evenly mixing RH-40 and maquindox ; a step 2) of fully melting and then starting a stirrer, wherein the stirring speed is 150-200 rpm; a step 3) of: after the temperature reaches 40-60 DEG C, stopping stirring, adding cinnamaldehyde, continuing to perform stirring for 30 min; a step 4) of stopping stirring, adding hot distilled water dropwise at 40-60oC, and performing heat insulation for 1 h after the dropwise adding is completed; a step 5) of cooling, adding a sterilizing agent, and continuing to perform stirring; and a step 6) of cooling for filtering and discharging. The prepared nanoemulsion has no acute toxicity reaction, no irritation and no allergic reaction, the effective rate is 95% or above, and the nanoemulsion is a medicine stable in quality and safe to use. The method for preparing the maquindox nanoemulsion is simple in process, controllable in quality, good in antibacterial effectand is expected to be used clinically.

Description

technical field [0001] The invention relates to the field of nanoemulsion preparation, in particular to an acetylmequina nanoemulsion and a preparation method thereof. Background technique [0002] Nanoemulsion (nanoemulsion), also known as microemulsion (microemulsion), is formed spontaneously by water, oil, EL-40 and 1,2-propanediol, etc., with a particle size of 1-100nm, thermodynamically stable, isotropic, transparent or translucent In general, nanoemulsions are divided into three types, namely, oil-in-water nanoemulsion (O / W), water-in-oil type nanoemulsion (W / O and bicontinuous nanoemulsion (B.C) , This dispersion system was first discovered and reported by Hoar and Schulman in 1943. It was not until 1959 that Schulman proposed the concept of "microemulsion". Since then, the theory and application research of nanoemulsion has developed rapidly. At present, nanoemulsion The technology has penetrated into the fields of daily chemical industry, fine chemical industry, pe...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/498A61P31/04A61P1/12A61P1/00A61P17/00A61P31/10
CPCA61K9/1075A61K9/0014A61K31/498A61K47/44
Inventor 姜迪蛟
Owner CHENGDU LINGXI SHANGPIN TECH CO LTD
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