Application of fibulin-3 as a target in the preparation of drugs for preventing and treating psoriasis
A fibulin-3 and psoriasis technology, applied in the field of biomedicine, can solve the problems of vascular proliferation and poor prognosis of tumors, and achieve the effect of improving erythema and clear intervention targets.
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[0025] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.
[0026] The present invention found that the expression of Fibulin-3 was increased in the skin lesions of patients with psoriasis and in the skin lesions of psoriasis mouse models induced by imiquimod. The expression of -3 increases; these suggest that Fibulin-3 is positively correlated with the development of psoriasis, and the present invention will be further described in detail below.
[0027] 1. Establishment of psoriasis mouse model
[0028] BALB / c female mice at the age of 6-7 weeks were purchased. Before the experiment, the mice were anesthetized by intraperitoneal injection of 5% chloral hydrate (0.1ml / 10g). Cage feeding. Apply 50 mg of 5% imiquimod cream to the back of the mice every day, and massage gently with one finger 30 times for 7 consecutive days.
[0029] 2. Treatment wit...
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