Application of fibulin-3 as a target in the preparation of drugs for preventing and treating psoriasis

A fibulin-3 and psoriasis technology, applied in the field of biomedicine, can solve the problems of vascular proliferation and poor prognosis of tumors, and achieve the effect of improving erythema and clear intervention targets.

Active Publication Date: 2019-12-27
XI AN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, there have been many biological studies on the role of Fibulin-3 in the development of tumors. It is reported that the methylation of the EFEMP1 gene promoter can reduce the expression of Fibulin-3, thereby leading to the proliferation of blood vessels in tumor tissues and poor prognosis of tumors.

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  • Application of fibulin-3 as a target in the preparation of drugs for preventing and treating psoriasis
  • Application of fibulin-3 as a target in the preparation of drugs for preventing and treating psoriasis
  • Application of fibulin-3 as a target in the preparation of drugs for preventing and treating psoriasis

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Embodiment Construction

[0025] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0026] The present invention found that the expression of Fibulin-3 was increased in the skin lesions of patients with psoriasis and in the skin lesions of psoriasis mouse models induced by imiquimod. The expression of -3 increases; these suggest that Fibulin-3 is positively correlated with the development of psoriasis, and the present invention will be further described in detail below.

[0027] 1. Establishment of psoriasis mouse model

[0028] BALB / c female mice at the age of 6-7 weeks were purchased. Before the experiment, the mice were anesthetized by intraperitoneal injection of 5% chloral hydrate (0.1ml / 10g). Cage feeding. Apply 50 mg of 5% imiquimod cream to the back of the mice every day, and massage gently with one finger 30 times for 7 consecutive days.

[0029] 2. Treatment wit...

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Abstract

The invention discloses the application of Fibulin-3 as a target in the preparation of a medicine for preventing and treating psoriasis, wherein the medicine takes Fibulin-3 as a drug target at the gene level and / or protein level. Fibulin-3 is positively correlated with the development of psoriasis. Treatment of imiquimod-induced psoriasis mouse model with appropriate concentration of Fibulin-3 antibody can improve erythema, scale and skin lesion thickness, and can reduce vascular endothelial Cells express VEGF, which reduces the proliferation and migration of vascular endothelial cells to inhibit the development of psoriasis and promote the recovery of skin lesions. Compared with other psoriasis drugs, Fibulin-3 antibody has a clearer intervention target, that is, for psoriasis In the early stage of the disease, there are pathological changes such as tortuosity and tension resistance of superficial dermal blood vessels and vascular proliferation.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to the application of Fibulin-3 in the preparation and prevention of psoriasis. Background technique [0002] Psoriasis is a chronic inflammatory skin disease with a high incidence and a long course. It mainly targets young and middle-aged people. The disease affects about 1% to 3% of the world's population. In recent years, with changes in climate, environment, diet, etc., the incidence rate is still rising. In addition to the economic burden, patients with serious illnesses also cause the loss of social labor force. Therefore, psoriasis has a great negative impact on patients' physical and mental health and daily life. The main pathological changes of psoriasis are the excessive proliferation and abnormal differentiation of epidermal keratinocytes, the infiltration of inflammatory cells in the epidermis, and the tortuous hyperplasia of blood vessels in the superficial dermis. B...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G01N33/68A61K45/00A61K39/395A61P17/06
CPCA61K45/00A61K2039/505C07K16/22C12Q1/6883C12Q2600/106G01N33/6863G01N2800/205
Inventor 郑焱王芯屈小燕杨珮雯景慧玲
Owner XI AN JIAOTONG UNIV
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