Insomnia treatment traditional Chinese medicine composition and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of drugs for the treatment of insomnia, to achieve the effect of small side effects

Active Publication Date: 2018-03-06
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on the above understanding, the ancients and the present have created a large number of prescriptions, and many prescriptions have definite curative effects. However, many prescriptions are personalized treatment plans, and there are few traditional Chinese medicine prescriptions suitable for industrial production.

Method used

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  • Insomnia treatment traditional Chinese medicine composition and preparation method thereof
  • Insomnia treatment traditional Chinese medicine composition and preparation method thereof
  • Insomnia treatment traditional Chinese medicine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 50 parts of fried jujube kernels, 10 parts of Yejiao vine, 10 parts of Baiziren, 10 parts of vinegar schisandra, 9 parts of coptis, 6 parts of albizia jujube, 6 parts of salvia miltiorrhiza, 6 parts of hypericum perforatum, and 0.6 parts of pearl powder.

[0029] Alcohol extraction: Properly pulverize the above-mentioned fried jujube kernels, vines, cypress kernels and Albizia julibrissin respectively, mix them, put them in a multifunctional extraction tank, and add 8 to 10 times the amount of 70% ethanol for extraction. The extraction time is 2h, extract twice, combine the extracts, filter with gauze, concentrate the filtrate in a single-effect concentrator, the concentration conditions are: pressure -0.08MPa, temperature 60°C, concentrate to concentrated solution A with a relative density of 1.28-1.30.

[0030] Water extraction: mix the above dregs with vinegar Schisandra, Coptis chinensis, Salvia perforatum and Hypericum perforatum evenly, add 8 to 10 times the a...

Embodiment 2

[0033] Take 100 parts of fried jujube kernels, 10 parts of Yejiao vine, 5 parts of Baiziren, 5 parts of vinegar schisandra, 15 parts of coptis, 10 parts of albizia jujube, 5 parts of salvia miltiorrhiza, 10 parts of Hypericum perforatum, and 0.2 parts of pearl powder.

[0034] Water extraction: Properly crush each component of the raw material drug (except pearl powder), after mixing, add 8 to 10 times the amount of water in the multi-functional extraction tank for extraction, the extraction time is 2 hours, extract twice, and combine the extraction liquid, filtered through gauze, and the filtrate was concentrated in a single-effect concentrator, the concentration conditions were: pressure -0.08MPa, temperature 70°C, concentrated to a concentrated solution A with a relative density of 1.13 to 1.15.

[0035] Alcohol precipitation: Slowly add ethanol to the concentrated solution A, stir while adding, so that the final alcohol concentration reaches 70%, leave it overnight, filter,...

Embodiment 3

[0038] Take 10 parts of fried jujube kernels, 50 parts of Yejiao vine, 50 parts of Baiziren, 20 parts of vinegar schisandra, 5 parts of coptis, 30 parts of albizia juniper, 50 parts of salvia, 5 parts of Hypericum perforatum, and 1 part of pearl powder.

[0039] Water extraction: Properly crush each component of the raw material drug (except pearl powder), after mixing, add 8 to 10 times the amount of water in the multi-functional extraction tank for extraction, the extraction time is 2 hours, extract twice, and combine the extraction liquid, filtered through gauze, and the filtrate was concentrated in a single-effect concentrator under the following conditions: pressure -0.08MPa, temperature 60°C, and concentrated to a concentrated solution A with a relative density of 1.28 to 1.30.

[0040] Drying: Put the concentrated solution A in a belt dryer to dry, the drying time is 2 hours, and the drying temperature is 85°C to obtain a dried product, then crush the dried product, and ...

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Abstract

The invention discloses an insomnia treatment traditional Chinese medicine composition and a preparation method thereof, wherein the insomnia treatment traditional Chinese medicine composition is prepared from the following raw materials by weight: 10-100 parts of fried ziziphus jujuba mill.var.spinosa, 10-50 parts of tuber fleeceflower stem, 5-50 parts of semen biotae shelled, 5-30 parts of schisandra chinensis processed with vinegar, 5-30 parts of coptis chinensis, 5-30 parts of albizzia julibrissin durazz, 5-50 parts of salvia miltiorrhiza, 5-25 parts of hypericum perforatum l, and 0.2-2 parts of pearl powder. The preparation method comprises: extracting the herbs, concentrating to obtain a concentrated liquid, drying, adding the pearl powder, and uniformly mixing so as to prepare tablets, oral liquids, granules, dripping pills or capsules. According to the present invention, the insomnia treatment traditional Chinese medicine composition has effects of blood enriching, nerve calming, heat clearing and irritability eliminating, mainly treats insomnia caused by liver-blood deficiency anddisturbance of deficiency-heat inside the body, treats syndrome such as difficulty in fallingasleep, dreaminess, festless sleep or early awakening, restlessness, red tongue and small pulse, is suitable for insomnia, has low side effect compared to a certain western medicine, and the preparation method is suitable for industrial production.

Description

technical field [0001] The invention relates to the field of drugs for treating insomnia, in particular to a traditional Chinese medicine composition for treating insomnia and a preparation method thereof. Background technique [0002] According to the "Guidelines for the Diagnosis and Treatment of Insomnia in Chinese Adults" issued by the Sleep Disorders Group of the Neurology Branch of the Chinese Medical Association in 2012, insomnia refers to a subjective experience of patients who are not satisfied with sleep time and / or quality and affect daytime social function. . Its main manifestations are difficulty in falling asleep, difficulty in maintaining sleep, premature awakening and no sense of recovery after sleep, which can cause physical dysfunction or obvious discomfort. Epidemiological surveys show that the rate of insomnia is as high as 10% to 20%. It is estimated that by 2020, there will be more than 700 million insomniacs worldwide. Generally speaking, the insomn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/725A61P25/20A61K35/618
CPCA61K35/618A61K36/14A61K36/38A61K36/48A61K36/537A61K36/57A61K36/704A61K36/718A61K36/725A61K36/79A61K2236/33A61K2236/331A61K2236/53A61K2300/00
Inventor 萧伟吴云商晶张红李英廉源沛韩兆忠田恒勇丁岗王振中
Owner JIANGSU KANION PHARMA CO LTD
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