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Preparation method for sodium aescinate

A technology of sodium aescinate and sodium hydroxide, which is applied to the preparation of sugar derivatives, chemical instruments and methods, steroids, etc., can solve the problems of unfavorable waste treatment, high solvent consumption, and low total yield, and meet the construction deadline The effect of shortening, overcoming environmental pollution, and increasing yield

Inactive Publication Date: 2018-03-06
黑龙江迪龙制药有限公司
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0004] At present, the method for preparing sodium aescinate from the seeds of the current prior art has a total yield of about 3%, but the method still has a low total yield, and consumes a lot of solvents, which is not conducive to the treatment of three wastes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Pulverize the Tianshi Lijingguo (ripe Tianshi Lijingguo after removing the peel) into a coarse powder of about 0.3cm (the size of a rice grain) with a grinder.

[0025] 2 leaching

[0026] 2.1 Weigh 600kg Tianshi chestnut pure fruit powder, put it in a 6T leaching tank, add 2500kg of 35%±5% methanol purified aqueous solution, and cold leaching for 24-36h. Stir and circulate once every 2 hours.

[0027] 2.2 Put the primary extraction liquid through the filter into the extraction temporary storage tank for later use.

[0028] 2.3 Add 35%±5% methanol purified aqueous solution to a 2000Kg leaching tank, and leaching for 12-24h. Stir and circulate once every 2 hours.

[0029] 2.4 Put the secondary extraction solution into temporary storage tanks (5T, 2 pieces) through the filter.

[0030] 3 Chloroform extraction and recovery

[0031] 3.1 Put the extract into extraction tanks (3.5T, 2 pieces), add saturated oxalic acid (reagent grade) aqueous solution (10-20L), adjust...

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PUM

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Abstract

The invention provides a preparation method for sodium aescinate. The sodium aescinate is prepared from Semen Aesculi through crushing, extraction, separation and purification. The preparation methodis characterized in that in the step of separation, the crude extract of Semen Aesculi is added into a saturated aqueous oxalic acid solution; then chloroform is used for extraction; and obtained chloroform extract is added into a cation exchange resin column treated with a sodium hydroxide solution so as to prepare sodium aescinate. The method provided by the invention is high in overall yield, low in solvent consumption and beneficial for treatment of waste gas, waste water and industrial residues.

Description

technical field [0001] The invention provides a preparation method of sodium aescinate, in particular, relates to a preparation method of extracting sodium aescinate from the ripe and dry fruit of the Aesculus aesculus Chestnut. It belongs to the field of natural medicinal chemistry. Background technique [0002] The dried and mature seeds of Aesculus wilsonii Rehd are commonly used Chinese herbal medicines "Sau Luozi" recorded in the Chinese Pharmacopoeia. It has the effects of soothing the liver, regulating qi, harmonizing the stomach, relieving pain and killing insects. Modern medical research shows that sala seeds have definite curative effects in anti-tumor, anti-brain edema, treatment of hypertensive cerebral hemorrhage, coronary heart disease, Meniere's disease, senile bronchial asthma, and facial neuritis. [0003] The main medicinal ingredient of Sala seed is aescin. CN102532241A discloses that the sage is crushed and then extracted by ethanol reflux, the extract ...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256C07H1/08
CPCC07J63/008C07H1/08C07H15/256
Inventor 董继胜于芳刘小丹
Owner 黑龙江迪龙制药有限公司
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