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Medicinal composition for relieving fever and easing pain

An antipyretic analgesic and composition technology, applied in the field of pharmaceutical preparations, can solve problems such as liver and kidney function damage, easy addiction, adverse reactions, etc., and achieve the effect of reducing side effects

Inactive Publication Date: 2018-03-09
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The phenobarbital in Qutong Tablets has a sedative and hypnotic effect and can improve the pain stimulation effect, but it is easy to become addicted to long-term use
In addition, phenacetin and aminopyrine in Qutong tablets have obvious adverse reactions
Long-term use can cause liver and kidney damage

Method used

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  • Medicinal composition for relieving fever and easing pain
  • Medicinal composition for relieving fever and easing pain
  • Medicinal composition for relieving fever and easing pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prescription (makes 1000 tablets):

[0022] Main ingredients: aminopyrine 140g phenacetin 140g

[0023] Caffeine 44g Phenobarbital 15g

[0024] Excipients: Starch 30.5g Magnesium Stearate 0.875g

[0025] Starch slurry (10%) 13-15g

Embodiment 2

[0027] Prescription (makes 1000 tablets):

[0028] Main ingredients: aminopyrine 120g phenacetin 120g

[0029] Caffeine 35g Phenobarbital 12g

[0030] Excipients: Starch 40.5g Magnesium Stearate 0.675g

[0031] Starch slurry (10%) 23-25g

Embodiment 3

[0033] Prescription (makes 1000 tablets):

[0034] Main ingredients: aminopyrine 135g, phenacetin 135g

[0035] Caffeine 40g Phenobarbital 12g

[0036] Excipients: Starch 40.5g Magnesium Stearate 0.675g

[0037] Starch slurry (10%) 23-25g

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Abstract

The invention discloses a medicinal composition for relieving fever and easing pain. The medicinal composition is characterized by being composed of aminopyrine, phenacetin, caffeine, phenobarbital and medicinal auxiliary materials. The aminopyrine and the phenacetin are capable of inhibiting synthesis and release of thalamus opticus prostaglandin and recovering orthocrasia of heat-regulating center receptive neuron and play a role of fever relieving; meanwhile a function of pain easing is also achieved by inhibiting synthesis of prostaglandin and the like; the aminopyrine is capable of inhibiting synthesis and release of aminopyrine in partial inflammation tissue, stabilizing lysosomal enzyme and influencing phagocytosis of phagocyte and plays a role of antiinflammatory action; the caffeine is a central nervous stimulant which is capable of stimulating cerebral cortex and improving the irritability to the external world and has the effects of shrinking brain blood vessels and enhancing the effects of the two former medicines in relieving headache; the phenobarbital has functions of calming, hypnosis and anticonvulsion, the calming functions of aminopyrine and phenacetin are enhanced, and convulsions caused by fever can be also prevented.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to an antipyretic and analgesic pharmaceutical composition. Background technique [0002] Qutong Tablets, also known as Analgesic Tablets or Somy Pain, is a compound preparation whose main ingredients are phenacetin, caffeine, and phenobarbital. Phenobarbital in Qutong Tablets has a sedative and hypnotic effect and can improve the pain stimulation effect, but it is easy to become addicted to long-term use. In addition, phenacetin and aminopyrine in Qutong Tablets had obvious adverse reactions. Long-term use can cause damage to liver and kidney function. How to rationally match prescriptions and reduce the drug side effects of Qutong Tablets is the problem to be solved by the present invention. Contents of the invention [0003] The present invention aims to provide an antipyretic and analgesic pharmaceutical composition. [0004] In order to achieve the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/515A61K31/522A61K31/4152A61K31/167A61P29/00
CPCA61K31/167A61K31/4152A61K31/515A61K31/522A61K2300/00
Inventor 曾培安刘娟吴健民贺莲
Owner KAMP PHARMA
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