Prefrontal cortex processing disorders, gait and limb disorders treatment
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A technology for physical impairments and disorders, applied in the field of drug intervention, disorders secondary to diseases or disorders, capable of addressing weakness, pain, etc.
Active Publication Date: 2021-07-13
GILROSE PHARMA
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Injectable drugs, such as interferon derivatives, especially (peginterferon beta-1a), which is known in the treatment of multiple sclerosis, and such injections can cause debilitating pain
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[0054] participant 1
[0055] Participant 1 was a male and was 8 years old when the pharmaceutical intervention of the present invention was first administered. Participant 1 had speech delay. Participant 1 was diagnosed with spastic diplegia, bilateral contractures at the hip joint. Participant 1 wore a leg brace before the drug intervention and had it removed at the initial visit. Participant 1 was treated with Botox injections, oral baclofen and orthotics before the drug intervention of the present invention. The parents of participant 1 discontinued all these treatments because they did not observe any gait improvement.
[0056] The initial drug intervention was 2 mL (10 mg) One month later it was replaced with 5 mg racemic methylphenidate (MPD / day. For participant 1 figure 1 and figure 2 Gait improvement is shown approximately 45 minutes after the initial visit and after daily treatment with 5 mg methylphenidate.
[0057] participant 2
[0058] Participant 2...
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Abstract
A methylphenidate, particularly comprising dex-threo-methylphenidate, administered to a subject for the treatment of gait or limb disturbance secondary to a genetically acquired prefrontal cortex processing disease or condition, wherein the prefrontal cortex processing Diseases or conditions specifically include multiple sclerosis, cerebral palsy, Angelman syndrome, Rett syndrome and fragile X syndrome.
Description
[0001] previous related applications [0002] This application is a PCT application of U.S. Serial No. 14 / 793,829, filed July 8, 2015, now US 9,307,942, and also claims priority to U.S. Serial No. 14 / 971,325, filed December 16, 2015, now Serial No. _____, which is a divisional application of the above-mentioned U.S. Serial No. 14 / 793,829, filed July 8, 2015, now US9,307,942, and also claims U.S. Serial No. 15, filed March 21, 2016 / 075,375, which is a continuation-in-part of the aforementioned U.S. Serial No. 14 / 971,325, filed December 16, 2015, and also claims U.S. Serial No. 14 / 881,516, filed October 13, 2015, now Priority to US 9,333,198, which is the aforementioned divisional application of US Serial No. 14 / 793,829, filed July 8, 2015, which applications are hereby incorporated by reference in their entirety. technical field [0003] The present invention relates to a pharmaceutical intervention and method for the treatment of gait or limb disorders, particularly includin...
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