Preparation to prevent and treat gingival recession and preparation method thereof

A gingival recession and preparation technology, applied in the field of preparations and preparations for preventing gingival recession, can solve the problems of long recovery period, patient pain, and inability to prevent it, and achieve the effect of inhibiting proliferation and effective treatment of gingival recession

Active Publication Date: 2018-05-25
LISHUI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the current treatment for gingival recession is still mainly surgical repair, but this will not only bring pain to the patient, but also take a long recovery period, which will bring more inconvenience to the life of the patient
Moreover, the method of surgical repair can only play the role of remedial after the onset, but can not play a preventive effect.

Method used

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  • Preparation to prevent and treat gingival recession and preparation method thereof
  • Preparation to prevent and treat gingival recession and preparation method thereof
  • Preparation to prevent and treat gingival recession and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0052] And the preparation technology of above-mentioned green fruit monomer extract can refer to as follows:

[0053]After the green fruit is cleaned, its seeds are separated, and the remaining part after the separation of the seeds is crushed, and the obtained crushed product is subjected to volatile oil extraction in an essential oil extractor, and the extracted volatile oil is the green fruit extract;

[0054] After testing, the MIC of the green fruit extract extracted by the above method can reach 0.0825ml / ml for Porphyrophyllum gingivalis.

[0055] At the same time, preferably, the hop extract is the water extract and / or alcohol extract of effective parts of hops or hop monomer; more preferably, the hop extract is the extract of hop monomer;

[0056] And the preparation technology of above-mentioned hops extract can refer to as follows:

[0057] After the hops are pulverized, they are pressurized, and the pressed water solution and residue are collected separately;

[...

Embodiment 1

[0082] (a) Raw material preparation:

[0083] Preparation of Artemisia argyi leaf extract: Wash and crush fresh Artemisia argyi leaves, pressurize continuously at 4°C, collect the leachate, add water to the residue after pressing, mix well and then press again, extract 3 times in a row, and squeeze the mixed aqueous solution through a 1000-mesh nylon filter Filtrate to remove insoluble residues, precipitate the filtrate with 60% ethanol, separate and precipitate with water-ethyl acetate for liquid-liquid extraction, collect the water phase, concentrate after rotary evaporation, freeze-dry and store at low temperature, which is the extract of Artemisia argyi ;

[0084] Preparation of green fruit extract: wash the fresh green fruit, separate the seeds, pulverize with a pulverizer, put the crushed product into an essential oil extractor for volatile oil extraction, and store the harvested volatile oil at low temperature, which is the green fruit extract;

[0085] Preparation of ...

Embodiment 2

[0092] With reference to the method of Example 1, respectively obtain the Artemisia argyi extract, the green fruit extract emulsion, and the hop extract;

[0093] To 1L of water, add 15ml mugwort leaf extract, 0.5g green fruit extract emulsion, 15ml hops extract, 1.2g nifedipine, 3g sodium chloride, and an appropriate amount of flavoring agent and preservative, and mix evenly to obtain Example 2 anti-gum recession mouthwash.

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Abstract

The invention provides a preparation to prevent and treat gingival recession and a preparation method thereof. The preparation herein is mainly made from various antibacterial plant extracts, such asargy wormwood leaf extract, Chinese white olive extract and European hop flower extract, as well as nifedipine that can stimulate proliferation of gum fibroblasts; the cooperative use of the above materials can effectively inhibit the proliferation of oral anaerobic bacteria and can also effectively treat gingival recession.

Description

technical field [0001] The invention relates to the field of oral health care, in particular to a preparation for preventing and treating gingival recession and a preparation method thereof. Background technique [0002] Gingival recession is a degenerative lesion of the gums and alveolar bone tissue, manifested as gingival recession, tooth neck or root exposure, and is also a common clinical refractory disease. It has been reported that almost 100% of people over the age of 50 have Different degrees of gingival recession. The main causes of gingival recession mainly include: the pressure of calculus on the gums in the neck of the teeth; the long-term disuse of the teeth in this part or systemic factors; the mechanical stimulation caused by incorrect brushing methods; the compression of the gums by the prosthesis, etc. After the gums have receded to a certain extent, the roots of the teeth will be exposed and the teeth will become loose, which is also an important reason fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61K8/9789A61K8/49A61Q11/00A61P1/02A61K31/4422
CPCA61K8/4926A61K8/97A61K31/4422A61K36/282A61K36/32A61K36/60A61K2800/28A61Q11/00A61K2300/00
Inventor 朱菊红周东方杨如会
Owner LISHUI UNIV
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