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Method and system for treating obesity-linked diseases by oral administration of active receptor activator

An active activator and diabetes technology, which is applied in the fields of pharmaceutical formulations, preparations for in vivo tests, compound screening/testing, etc., can solve problems such as high costs, and achieve the effects of simple methods and systems, good promotion and feasibility

Inactive Publication Date: 2018-05-29
WENZHOU MEDICAL UNIV
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AI Technical Summary

Problems solved by technology

[0008] The utility model overcomes the high cost problem of β-cell gene knockout mice by constructing a type II diabetes mouse model, and simplifies the experiment for verifying the therapeutic effect of oral active activators on obesity-related diseases (such as type II diabetes)

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0009] 1. Preparation and grouping of type II diabetes mouse model

[0010] 40 12-week-old male C57BL / 6 mice (purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences), 40 SPF male C57 / BL6 mice (adaptive feeding for 1 week, randomly divided into 10 normal control NC groups) With 30 of the experimental group, the NC group was given conventional feed, and the experimental group was fed with high-sugar and high-fat diet (66.5%+20% brown sugar+10% lard+2.5% cholesterol+1% bile salt of conventional feed). After 5 weeks , fasting for 12 hours, intraperitoneally injecting 1% streptozotocin 40mg / kg to induce diabetes model, fasting for 4 hours after 72 hours, taking blood from the tail to measure FPG. Blood glucose concentration> 11mmol / L, and polydipsia, polyphagia, polyphagia The urinary symptoms suggested that the diabetic mouse model was successfully induced. Treatment once a day: the mice in the DM+L group were fed with AdipoRon at a dose of 1.25 mg / kg; the...

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Abstract

The study is different from other studies in the prior art, and a biological method is used to explore the mechanism of action of AdipoRon on the treatment of type 2 diabetes. Liver cells are used asan experimental subject for construction of an experimental group blocking a P13 / Akt signaling pathway, then the AdipoRon acts, and expression of related carbohydrate genes of the liver cells is analyzed to investigate the cellular mechanism of the AdipoRon on the treatment of the type 2 diabetes. At present, the study is not reported at home and abroad. Almost all methods for treating the type 2diabetes require proper diet and exercise, and produce adverse effects such as hypoglycemia and weight gain, by oral administration of the AdipoRon, excess calorie intake can be safely reduced, and consequence caused by a sedentary lifestyle can be reduced, so that the AdipoRon provides a novel treatment method, a lot of money for purchase of db / db mice and double gene knockout mice can be saved.

Description

technical field [0001] Orally active receptor agonists are used in the field of treatment of obesity-related diseases (such as type II diabetes), especially related to the feasibility of AdipoRon (a kind of adiponectin receptor activity activator) for the treatment of type II diabetes. Background technique [0002] Studies have shown that diabetes has become an endocrine and metabolic disease that seriously threatens human health. Type II diabetes accounts for more than 95% of diabetic patients. The risk of malignant tumors such as colorectal cancer, liver cancer, and breast cancer in patients with type II diabetes is significantly higher than that of the general population. Insulin resistance is a common cause of diseases such as type II diabetes and cardiovascular disease in obese and susceptible individuals. [0003] At present, the drugs for the treatment of type II diabetes are mainly oral hypoglycemic drugs, but they are often accompanied by some serious adverse reac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
CPCA61K49/0008
Inventor 肖敏
Owner WENZHOU MEDICAL UNIV
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