Method and system for treating type 2 diabetes mellitus by using astaxanthin extract

A technology for type 2 diabetes and type 2 diabetes, which is applied in biochemical equipment and methods, microbial determination/inspection, animal husbandry, etc., can solve problems such as high cost, and achieve simple methods and systems, good popularization and feasibility. Effect

Inactive Publication Date: 2021-12-07
WENZHOU MEDICAL UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention overcomes the high-cost problem of β-cell gene knockout mice by constructing a type 2 diabetes mouse model, and simplifies the experiment for verifying the therapeutic effect of astaxanthin extract on obesity-related diseases (such as type 2 diabetes)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method and system for treating type 2 diabetes mellitus by using astaxanthin extract
  • Method and system for treating type 2 diabetes mellitus by using astaxanthin extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] 1. Preparation of type 2 diabetes mouse model, group processing and histological examination

[0009] 40 12-week-old male C57BL / 6 mice (purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences), 40 SPF male C57BL / 6 mice (adaptive feeding for 1 week, randomly divided into 10 normal control NC groups) And the experimental group 30, the NC group was given conventional feed, the experimental group was given high sugar and high fat (MD12031 (gm% / kacl%) protein 19.2 / 20 fat 4.30 / 10 carbohydrate 67.3 / 70 trace elements 9.20 / 0) diet feeding. After 5 weeks, fast for 12 hours, intraperitoneally inject 1% streptozotocin 40mg / kg to induce diabetes model, fast for 4 hours after 72 hours, and take blood to measure FPG. Blood glucose concentration> 11.8mmol / L, and polydipsia, The symptoms of polyphagia and polyuria suggested that the diabetic mouse model was successfully induced. Administration of astaxanthin was divided into model control (DM) group, model + low ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The research is different from other previous researches, and the action mechanism of the astaxanthin extract for treating the type 2 diabetes mellitus is discussed by applying a biological method. According to the method, skeletal muscle cells are taken as experimental subjects, an experimental group for blocking a P13/Akt signal channel is constructed, then the astaxanthin extract is given, hepatic cell related carbohydrate gene expression is analyzed, and the cellular mechanism of the astaxanthin extract for treating type 2 diabetes mellitus is discussed. At present, the research is not reported at home and abroad. Therefore, a novel treatment method is provided through the astaxanthin extract. By using the method, lots of expenditures for purchasing db/db mice and double-gene knockout mice can be saved. According to the research, the protein expression level of an insulin receptor substrate P-IRS-1 is measured, then the influence of the astaxanthin extract on the insulin sensitivity of mouse myoblasts (C2C12) is detected, and a theoretical basis is provided for treatment of type 2 diabetes mellitus.

Description

technical field [0001] The field of treating obesity-related diseases (such as type 2 diabetes) by astaxanthin extract particularly relates to verifying the feasibility of treating type 2 diabetes by astaxanthin extract. Background technique [0002] Studies have shown that diabetes has become an endocrine and metabolic disease that seriously threatens human health. Type II diabetes accounts for more than 95% of diabetic patients. Type II diabetes is mainly caused by the interaction of peripheral insulin resistance and decreased B cell secretion. Insulin resistance alone does not necessarily lead to type 2 diabetes. Therefore, an ideal treatment for type II diabetes should take into account the above two pathogenesis. [0003] The chemical name of astaxanthin is 3,3′-dihydroxy-4,4′-diketone-β,β′-carotene, which is an unsaturated terpene compound and is the strongest antioxidant found in nature so far. , has a variety of physiological effects, has the ability to promote c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/027G01N33/573C12Q1/6851
CPCA01K67/027G01N33/573C12Q1/6851A01K2207/25A01K2227/105A01K2267/0362C12Q2531/113C12Q2561/113C12Q2563/107
Inventor 肖敏
Owner WENZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap