Method and system for treating type 2 diabetes mellitus by catalpol extract

A type 2 diabetes and extract technology, which is applied in the field of treatment of type 2 diabetes and system with catalpol extract, can solve the problems of high cost and achieve good promotion and feasibility

Pending Publication Date: 2021-04-23
WENZHOU MEDICAL UNIV
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention overcomes the high cost problem of β-cell gene knockout mice by constructing a type 2 diabetes mouse model, and simplifies the experiment for verifying the therapeutic effect of catalpol extract on obesity-related diseases (such as type 2 diabetes)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method and system for treating type 2 diabetes mellitus by catalpol extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0009] 1. Preparation of type 2 diabetes mouse model, group processing and histological examination

[0010] 40 12-week-old male C57BL / 6 mice (purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences), 40 SPF male C57BL / 6 mice (adaptive feeding for 1 week, randomly divided into 10 normal control NC groups) And the experimental group 30, the NC group was given conventional feed, the experimental group was given high sugar and high fat (MD12031 (gm% / kacl%) protein 19.2 / 20 fat 4.30 / 10 carbohydrate 67.3 / 70 trace elements 9.20 / 0) diet feeding. After 5 weeks, fast for 12 hours, intraperitoneally inject 1% streptozotocin 40mg / kg to induce diabetes model, fast for 4 hours after 72 hours, and take blood to measure FPG. Blood glucose concentration> 11.8mmol / L, and polydipsia, The symptoms of polyphagia and polyuria suggested that the diabetic mouse model was successfully induced. Administration of catalpol was divided into model control (DM) group, model + low dos...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The research is different from other previous researches, and an action mechanism of a catalpol extract on treatment of type 2 diabetes mellitus is discussed by using a biological method. According to the method, skeletal muscle cells are taken as experimental objects, an experimental group for blocking a P13 / Akt signal path is constructed, the catalpol extract is given, liver cell related carbohydrate gene expression is analyzed, and a cellular mechanism of the catalpol extract on type 2 diabetes treatment is discussed. At present, the research is not reported at home and abroad. Therefore, the catalpol extract provides a novel treatment method. By using the method, a lot of expenditures for purchasing db / db mice and double-gene knockout mice can be saved. According to the research, the protein expression level of an insulin receptor substrate PIRS1 is determined, and then the influence of catalpol extract on the insulin sensitivity of a mouse myoblast cell strain (C2C12) is detected, so that a theoretical basis is provided for treatment of type 2 diabetes mellitus.

Description

technical field [0001] The field of treatment of catalpol extract on obesity-related diseases (such as type 2 diabetes), especially relates to the feasibility of verifying the treatment of catalpol extract on type 2 diabetes. Background technique [0002] Due to the great changes in human living environment and life style, the incidence of diabetes is increasing year by year. It has become the third largest non-communicable disease after cardiovascular disease and tumors. In recent years, the incidence of diabetes has been on the rise. Among diabetic patients, type II diabetes accounts for more than 95%. Type II diabetes is caused by multiple genes and environmental factors. It has a strong genetic susceptibility, insulin resistance and pancreatic β-cell Hypofunction is the main pathogenesis of type II diabetes. [0003] At present, the international treatment methods for type 2 diabetes include psychological treatment, health care treatment, and exercise treatment, while ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K49/00A61K31/7048A61P3/10
CPCA61K49/0008A61K31/7048A61P3/10
Inventor 肖敏
Owner WENZHOU MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap