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Tertiary amine compound and application thereof

A tertiary amine compound, compound technology, applied in organic chemistry, medical preparations containing active ingredients, dental preparations, etc., can solve problems such as deficiencies, and achieve the effect of solving flora imbalance

Active Publication Date: 2018-06-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, research on materials that can modify resin filling material systems and have pH-sensitive properties is still lacking.

Method used

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  • Tertiary amine compound and application thereof
  • Tertiary amine compound and application thereof
  • Tertiary amine compound and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Synthesis of methyl hexadecylamino ethyl methacrylate (Pro B, also referred to as 16 chain tertiary amine in the present invention)

[0045] (1) Synthesis of compound B2: In a 250ml round bottom flask, add compound hexadecane bromide (0.1mol, 25g, 25ml) and compound A2 (N-methylethanolamine) (5.0eq, 0.5mol, 32g, 34ml), and 80ml of isopropanol was added as a solvent, refluxed at 85°C for 8-10h, and a large amount of product was found to be formed by thin layer chromatography (TLC). Cool the system back to room temperature, pour the system into 150mL diethyl ether to dilute, and wash with water (3*150ml) and saturated brine (2*150ml), collect the organic phase, wash over anhydrous Na 2 SO 4 After drying, the solvent was removed under reduced pressure to obtain a colorless oil B (24 g, up to 99% yield).

[0046](2) Synthesis of compound Pro B: Add B2 (0.1mol, 24g) and methyl methacrylate (3.0eq, 0.3mol, 31.8ml) into a 100ml round bottom flask, and stir well. A...

Embodiment 2

[0047] Embodiment 2 dental antibacterial material

[0048] Take an appropriate amount of methylhexadecylaminoethyl methacrylate, mix it with the adhesive, and then it can be used as a dental antibacterial material.

[0049] The dental bacteriostatic material referred to in the present invention can be the product after methyl hexadecylamino ethyl methacrylate and adhesive are mixed, also can be the separated product.

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Abstract

The invention provides a novel tertiary amine compound. The novel tertiary amine compound can reduce the pH value of an environment under the action of acid-producing bacteria, performs antibacterialeffect, has the characteristic of pH value sensitivity, and overcomes the problem of dysbacteriosis due to lack of traditional antibacterial agents in selectivity.

Description

technical field [0001] The invention relates to a new tertiary amine compound and its application. Background technique [0002] Caries is one of the most common chronic diseases. As a plaque disease, the occurrence of caries is closely related to the plaque biofilm in the oral cavity. Plaque biofilm colonizes on the surface of tooth-acquired membrane, uses carbohydrates to produce extracellular matrix, and further grows and matures in it. The pH value of the microenvironment gradually decreases, and the microbial species transfer to acid-producing and acid-resistant bacteria, resulting in tooth demineralization and caries. Bad. [0003] Over the years, there have been a large number of related studies on the inhibition of plaque biofilm, such as chlorhexidine, hydrogen peroxide, fluorine preparations, nanomaterials, etc., in the form of solutions, suspensions, gels, etc. There are obvious effects; however, there are also some problems, such as chlorhexidine, hydrogen pero...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C219/08A61K31/221A61P31/04A61K6/02
CPCA61K6/80C07C219/08
Inventor 程磊梁静鸥周学东李明云李继遥任彪彭显冯明业徐华焜王素苹
Owner SICHUAN UNIV
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