Extraction and purification method of dioscin

A technology of diosgenin and a purification method, which is applied in the field of biomedicine, can solve the problems of large amount of organic solvent usage and long production time, and achieve the effects of improving purity, reducing dosage, and avoiding pretreatment

Inactive Publication Date: 2018-06-12
贯虹科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above diosgenin extraction and purification methods all have the disadvantages of long production time and large amount of organic solvents used

Method used

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  • Extraction and purification method of dioscin
  • Extraction and purification method of dioscin

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0067] In a preferred version, the preparation method of the dragon powder also includes the following steps:

[0068] Wash the rhizomes of Dioscoreaceae plants, dry the skins, and set aside;

[0069] Turn on the motor to drive the support shaft to drive the multi-layer drying net to rotate at a low speed;

[0070] The rhizomes of Dioscoreaceae plants are transported to a pair of extrusion rollers for crushing through the feeding hopper, and then fall into the low-speed rotating multi-layer drying net to be dried step by step until the water content is ≤6%. The specific steps of step-by-step drying include:

[0071] Turn on the heating blower to heat the rhizomes of the Dioscoreaceae plants to 80-82°C at a uniform speed within 30-50 minutes, then dry them at a constant temperature for 30-50 minutes; heat the roots of the Dioscoreaceae plants to 84-86°C, and then dry them at a constant temperature for 40 minutes. -60min;

[0072] heating the rhizome of the Dioscoreaceae plan...

Embodiment 1

[0086] 1.1 Superfine pulverization: take 1kg of Chugonosaurus, crush it through a crushing and drying device, and dry it step by step at 80-90°C until the water content is 6%. After superfine pulverization, the powder passes through a 300-mesh sieve to obtain superfine powder; The conditions for stage drying are as follows: heating the rhizomes of Dioscoreaceae plants to 80°C at a uniform speed within 40 minutes, and then drying them at a constant temperature for 50 minutes; The plant rhizome is then heated to 90°C and then dried at a constant temperature until the water content is 6%;

[0087] 1.2 Microwave-assisted ethanol reflux extraction of dioscin: take the ultrafine powder in 1.1, the solid-liquid ratio is 1:12, the ethanol concentration is 90%, the microwave power is 300W, the extraction time is 12min, the extraction temperature is 50°C, and the extraction is performed 5 times. Reflux for 60 minutes each time, and the reflux temperature is 45°C;

[0088] 1.3 Alcohol p...

Embodiment 2

[0092] 1.1 Superfine grinding: Take 1kg of brick yam (here according to your suggestion), crush it through a crushing and drying device and dry it step by step at 80-90°C until the water content is 5%. After superfine grinding, The powder is passed through a 300-mesh sieve to obtain ultra-fine powder; the step-by-step drying conditions are to heat the rootstock of the Dioscoreaceae plant at a uniform speed to 82°C within 30 minutes and then dry it at a constant temperature for 40 minutes; heat the rootstock of the Dioscoreaceae plant to Dry at 86°C for 60 minutes at a constant temperature; heat up the rhizomes of the Dioscoreaceae plant to 88°C and dry at a constant temperature until the water content is 5%;

[0093] 1.2 Microwave-assisted ethanol reflux extraction of dioscin: take the ultrafine powder in 1.1, the solid-liquid ratio is 1:14, the ethanol concentration is 85%, the microwave power is 400W, the extraction time is 15min, the extraction temperature is 45°C, and the e...

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Abstract

The invention discloses an extraction and purification method of dioscin. The extraction and purification method comprises the following steps of: after carrying out multiple circulating extraction treatment on a mixture of dioscoreaceae rhizome powder and organic solvents, filtering to obtain dioscin extracting solution, wherein each extraction treatment comprises microwave treatment and refluxing-method treatment which are carried out in sequence; purifying the dioscin extracting solution to obtain dioscin. The extraction and purification method disclosed by the invention has the beneficialeffects that the technical operation is simple, the use amount of the organic solvent is greatly reduced, the process time is shortened by 50% or more, acid and alkaline are not used, and the main organic solvents can be recycled respectively, so that the generation amount of 'three wastes' (waste water, waste gas and waste solid) after industrial production is greatly reduced.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for extracting and purifying diosgenin. Background technique [0002] Dioscin is composed of spirosterane-type diosgenin and a sugar chain connected to the 3-hydroxyl group connected by glycosidic bonds. It is a typical active natural saponin compound, which exists in Dioscoreaceae and Liliaceae. , Caryophyllaceae and Rosaceae and other medicinal plants, especially rich in Dioscoreaceae plants, such as Dioscorea punctatus, Dioscorea shield leaf and yellow yam. Traditional Chinese medicine believes that diosgenin has the functions of eliminating phlegm, relaxing tendons and activating blood circulation, eliminating food and diuresis. Modern pharmacological studies have shown that dioscin also has desensitization, anti-inflammatory, lipid-lowering, anti-tumor, liver-protecting, and anti-viral effects. Since diosgenin is linked with sugar residues, it is easily solubl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00
CPCC07J71/0005
Inventor 张春颖
Owner 贯虹科技有限公司
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