Fibrauretin and its extraction method and fibrauretin capsule and preparation method thereof

A technology of scutellarin and capsules, applied in the directions of capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of insufficient utilization of scutellaria medicinal materials, low treatment effect of gynecological inflammation, and poor content of scutellarin. It can restore the self-defense and self-purification ability, improve the utilization rate of medicinal materials, and improve the efficacy of medicines.

Active Publication Date: 2018-06-15
广东广发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method obtains the yield of palmatine content is low, and the medicinal material of palmatine can not be fully utilized, resulting in waste of resources. The acid extraction method is a better extraction process at present, but the extracti...

Method used

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  • Fibrauretin and its extraction method and fibrauretin capsule and preparation method thereof
  • Fibrauretin and its extraction method and fibrauretin capsule and preparation method thereof
  • Fibrauretin and its extraction method and fibrauretin capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] A process for extracting palmatine, comprising the steps of:

[0065] (1) One-time alcohol extraction: adding Chinese vine to 75% ethanol which is 7 times by weight of the Chinese vine, raising the temperature to 80-85° C. to boil the ethanol, keeping it warm for 2 hours, and filtering to obtain a primary filter residue and a primary filtrate;

[0066] (2) Secondary alcohol extraction: add the primary filter residue to 75% ethanol which is 6 times the weight of the primary filter residue, heat up to 80-85° C. to boil the ethanol, keep it warm for 2 hours, and filter to obtain the secondary filter residue and secondary filtrate;

[0067] (3) Three times of alcohol extraction: adding the secondary filter residue to 75% ethanol which is 5 times the weight of the secondary filter residue, heating up to 80-85° C. to boil the ethanol, keeping it warm for 2 hours, and filtering to obtain the third filtrate;

[0068] (4) Concentration under reduced pressure: the first filtrate,...

Embodiment 2

[0077] A process for extracting palmatine, comprising the steps of:

[0078] (1) One-time alcohol extraction: adding Chinese vine to 60% ethanol which is 6 times by weight of the Chinese vine, warming up to 85° C., keeping the temperature for 3 hours, and filtering to obtain a primary filter residue and a primary filtrate;

[0079] (2) Secondary alcohol extraction: add the primary filter residue to 60% ethanol which is 5 times the weight of the primary filter residue, heat up to 85° C., keep warm for 3 hours, and filter to obtain the secondary filter residue and secondary filtrate;

[0080] (3) Three times of alcohol extraction: adding the secondary filter residue to 60% ethanol which is 4 times the weight of the secondary filter residue, raising the temperature to 85° C., keeping the temperature for 3 hours, and filtering to obtain the third filtrate;

[0081] (4) concentrating under reduced pressure: the primary filtrate, the secondary filtrate and the third filtrate are com...

Embodiment 3

[0090] A process for extracting palmatine, comprising the steps of:

[0091] (1) One-time alcohol extraction: adding Huangteng to 90% ethanol with 8 weight times of said Huangteng, raising the temperature to 65° C., keeping it warm for 1 hour, and filtering to obtain a primary filter residue and a primary filtrate;

[0092] (2) Secondary alcohol extraction: add the primary filter residue to 90% ethanol which is 7 times the weight of the primary filter residue, heat up to 65° C., keep warm for 1 hour, and filter to obtain the secondary filter residue and secondary filtrate;

[0093] (3) Three times of alcohol extraction: adding the secondary filter residue to 90% ethanol which is 6 times the weight of the secondary filter residue, raising the temperature to 65° C., keeping it warm for 1 hour, and filtering to obtain the third filtrate;

[0094] (4) concentrating under reduced pressure: the primary filtrate, the secondary filtrate and the third filtrate are combined and concentr...

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Abstract

The invention relates to the technical field of traditional Chinese medicines and particularly relates to fibrauretin and its extraction method, a fibrauretin capsule and a preparation method of the fibrauretin capsule. The extraction method of fibrauretin comprises primary alcohol extraction, secondary alcohol extraction, tertiary alcohol extraction, vacuum concentration, salting-out precipitation, primary refining, secondary refining and crystallization. The fibrauretin has purity greater than or equal to 95.5%. The extraction method is simple and practical and has high efficiency and high extraction purity. The invention also provides the fibrauretin capsule and the preparation method thereof. The fibrauretin capsule has main effects of clearing away inner heat and removing toxins, andresisting bacteria and diminishing inflammation, can be used for treating gynecological inflammation, has a unique effect of treating both symptoms and root causes of chronic pelvic inflammatory diseases and vaginitis in women, has good treatment effects and has no toxic or side effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a palmatine, an extraction method, a palmatine capsule and a preparation method. Background technique [0002] Palmatine is the dried cane of Phantasmus vine, which mainly contains palmatine, jatrorrhizine and other alkaloids. Palmatine hydrochloride is palmatine hydrochloride, which is an alkaloid extracted and purified from the medicinal material Huangteng. The process of patinol adopts the acid extraction method to enrich the alkaloid parts in the acid water extract of medicinal materials, and then obtains the crude product of patinol after alkalization and salting out, and refines the crude product of pachyphyllum with ethanol to obtain patinacein. This method obtains the yield of palmatine content is low, and the medicinal material of palmatine can not be fully utilized, resulting in waste of resources. The acid extraction method is a better extraction...

Claims

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Application Information

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IPC IPC(8): C07D455/03A61K31/4375A61K9/48A61K36/8905A61P15/00A61P29/00A61P39/02A61P31/04
CPCA61K9/4808A61K31/4375A61K36/232A61K36/238A61K36/288A61K36/324A61K36/328A61K36/355A61K36/484A61K36/539A61K36/634A61K36/66A61K36/78A61K36/8905A61K2236/333A61K2236/39A61K2236/51A61K2236/53C07D455/03A61K2300/00
Inventor 高东翔姜学勇周亚林陈云红
Owner 广东广发制药有限公司
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