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A kind of traditional Chinese medicine cream and preparation method thereof

A technology for creams and traditional Chinese medicines, which is applied in the directions of pharmaceutical formula, drug delivery, ointment delivery, etc., and can solve the problems of oil-water separation and low content of active ingredients

Inactive Publication Date: 2020-08-25
SHANGHAI FANGXIN HEALTH TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In actual production, the inventors found that the yellow-white ointment sample prepared by the above-mentioned process had a low active ingredient content, and oil-water separation occurred after one year of storage.

Method used

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  • A kind of traditional Chinese medicine cream and preparation method thereof
  • A kind of traditional Chinese medicine cream and preparation method thereof
  • A kind of traditional Chinese medicine cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment one prepares yellow-white ointment with technique (new technique) of the present invention

[0021] Prescription: 18g of Huangyaozi, 18g of Baiyaozi, 24g of Comfrey, 24g of Rhubarb, 24g of Gardenia, 60g of Rehmannia, 15g of Blood, 24g of Angelica, 45g of Angelica, 45g of Frankincense and 45g of Myrrh.

[0022] (1) Weigh dried blood, frankincense, and myrrh by weight, grind them into fine powder, mix, add 10 times the amount of 95% ethanol, let stand overnight, filter, and concentrate the filtrate under reduced pressure to a liquid containing 1g of crude drug per 1ml Extract 105ml for later use;

[0023] (2) Take the eight medicinal materials such as xanthogonia, baiyaozi, comfrey, rhubarb, gardenia, habitat, angelica, angelica, etc. by weight, break the shell of gardenia, add 6 times the amount of 70% ethanol, extract 2 times, each time After 1.5 hours, filter, discard the medicinal residues, combine the filtrate, and concentrate the filtrate under reduced p...

Embodiment 2

[0027] Example 2 Comparison of analgesic efficacy and activity of Huangbai ointment samples prepared by different processes

[0028] (1) Test material:

[0029] Electronic balance, constant temperature water bath, iron plate, beaker, stopwatch, etc.

[0030] KM strain female mice with body weight in the range of 20-25g.

[0031] Tested samples: blank matrix, yellow-white ointment sample (A) prepared by old process (CN101310750B method) and yellow-white ointment sample (B) prepared by process of the present invention.

[0032] (2) Test method:

[0033] Using the hot plate method, when the temperature of the water bath is set to 57°C, the temperature of the beaker (hot plate) is exactly 55°C. First measure the pain threshold of each mouse twice, the average value is within 5-30 seconds, and the mice that do not appear abnormal behaviors such as jumping are qualified mice. Qualified mice were divided into 5 groups after shaving their backs, 12 in each group, and three samples...

Embodiment 3

[0041] Example 3 Determination of the content of geniposide and hematoxylin in Huangbai ointment prepared by different processes

[0042] Geniposide has a wide range of pharmacological effects in the digestive system, cardiovascular system, central nervous system and anti-inflammatory, anti-tumor, and hypoglycemic aspects; blood dried blood has the functions of promoting blood circulation and relieving pain, removing blood stasis and stopping bleeding, promoting muscle regeneration and reducing sores. It is used for bruises, confidant bruises, traumatic bleeding, sores and sores. It is a valuable medicinal material and an active ingredient. Therefore, choose geniposide and dried blood for content determination.

[0043] 3.1 Test method

[0044] According to the process of the present invention and the pilot test samples of Huangbai ointment prepared by the old process, the contents of geniposide and hematoxylin were determined. The new process sample batch numbers are: 20160...

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Abstract

The invention discloses a preparation method of a traditional Chinese medicinal cream. The method comprises the following steps: weighing dragon's blood, Boswellia carteri, myrrh, Airpotato Yam Rhizome, oriental stephania root, Lithospermum erythrorhizon, rheum officinale, Fructus Gardeniae, rehmannia root, dahurian angelica root and Chinese angelica root according to the prescription dosage of Huangbai ointment, and respectively processing above weighed medicinal materials to prepare as liquid extracts; preparing an oil phase from Vaseline, stearyl alcohol, liquid paraffin, stearic acid and monoglyceride, and preparing an aqueous phase from Tween-80, glycerin, ethylparaben and distilled water; and mixing and uniformly stirring the oil phase and the aqueous phase until the temperature reaches room temperature. The traditional Chinese medicinal cream prepared through the method has the advantages of strong analgesic activity, high stability, and suitableness for production and storage.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine technology, in particular to a traditional Chinese medicine ointment and a preparation method thereof. Background technique [0002] CN101310750B discloses the preparation method of Huangbai ointment (hereinafter referred to as "old technology") as follows: 6 parts of Xanthophyllum, 6 parts of Baiyaozi, 7 parts of Comfrey, 8 parts of Rhubarb, 8 parts of Gardenia, 20 parts of Rehmannia, and 5 parts of Dracaena japonicus , 8 parts of Angelica dahurica, 15 parts of angelica, 15 parts of frankincense, 15 parts of myrrh. Add water to decoct the eleven medicines in the above weight ratio twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.05, let it cool, add an equal amount of ethanol and stir Evenly, let it stand overnight, take the supernatant to recover ethanol, concentrate under reduced pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06
CPCA61K9/0014A61K9/06A61K36/232A61K36/30A61K36/324A61K36/328A61K36/59A61K36/708A61K36/744A61K36/804A61K36/889A61K36/8945A61K36/896A61K47/26A61K2236/333A61K2236/39A61K2300/00
Inventor 许勇李飞跃张昕
Owner SHANGHAI FANGXIN HEALTH TECH DEV